Role of berberine in Alzheimer's disease.
Role of berberine in Alzheimer's disease.
复制标题
小檗碱在阿尔茨海默病中的作用
DOI：
10.2147/ndt.s114846
复制
发表时间：
2016
影响因子：
3.2
通讯作者：
Yang W
中科院分区：
文献类型：
--
作者：
Cai Z;Wang C;Yang W
黄连素是一种重要的原黄连素异喹啉生物碱，具有抗菌、降血糖、降胆固醇、抗肿瘤和免疫调节等多种药理活性。大量研究表明，黄连素可能通过限制细胞外淀粉样斑块和细胞内神经纤维缠结的发病机制而有益于阿尔茨海默病(AD)。越来越多的证据表明，黄连素在与降脂降糖特性相关的动脉粥样硬化中具有保护作用，这意味着小连素有可能抑制AD的这些危险因素。本文还试图讨论黄连素可能延缓氧化应激和神经炎症的药理学基础，以显示其在AD中的保护作用。因此，黄连素可能被认为是预防或延缓AD进程的一种潜在的治疗方法。然而，有必要进行更详细的研究，并对黄连素进行安全性评估，以澄清黄连素在限制这些危险因素和AD相关病理方面的作用。
Berberine, an important protoberberine isoquinoline alkaloid, has several pharmacological activities, including antimicrobial, glucose- and cholesterol-lowering, antitumoral, and immunomodulatory properties. Substantial studies suggest that berberine may be beneficial to Alzheimer’s disease (AD) by limiting the pathogenesis of extracellular amyloid plaques and intracellular neurofibrillary tangles. Increasing evidence has indicated that berberine exerts a protective role in atherosclerosis related to lipid- and glucose-lowering properties, implicating that berberine has the potential to inhibit these risk factors for AD. This review also attempts to discuss the pharmacological basis through which berberine may retard oxidative stress and neuroinflammation to exhibit its protective role in AD. Accordingly, berberine might be considered a potential therapeutic approach to prevent or delay the process of AD. However, more detailed investigations along with a safety assessment of berberine are warranted to clarify the role of berberine in limiting these risk factors and AD-related pathologies.