Coffee, tea, and mortality.
Coffee, tea, and mortality.
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DOI：
10.1016/1047-2797(93)90064-b
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发表时间：
1993-07-01
影响因子：
5.6
通讯作者：
Friedman, G D
中科院分区：
文献类型：
--
作者：
Klatsky, A L;Armstrong, M A;Friedman, G D
除了关于咖啡和冠状动脉疾病风险的相互矛盾的证据外，咖啡和茶与主要死亡原因无关。由于饮料的广泛使用和先前研究的局限性，人们的担忧依然存在。使用COX模型(10个协变量)，我们研究了128,934人与4501例后续死亡的关系。在调整后的分析中，除了重度(>；或=4杯/d)咖啡使用者患急性心肌梗死的风险略有增加(相对风险=1.4，95%可信区间=1.0至1.9，P=0.07)外，所有死亡的死亡风险(每天每杯咖啡的相对风险=0.99，95%可信区间=0.97至1.01；每天每杯茶的相对风险=0.98，95%可信区间=0.96至1.00)或主要原因都没有增加。咖啡与较低的肝硬化死亡风险相关(每天每杯咖啡的相对风险=0.77，95%可信区间=0.67至0.89)。使用这两种饮料与较低的自杀风险有关，随着咖啡摄入量的增加(每天每杯咖啡的相对风险=0.87，95%可信区间=0.77至0.98)，自杀风险逐渐降低。我们得出结论，咖啡和茶与死亡风险没有总体关系。如果咖啡增加了冠状动脉疾病的风险，这与其他疾病(特别是肝硬变和自杀)的不明原因的较低风险相平衡。
Except for conflicting evidence about coffee and risk of coronary disease, coffee and tea are not linked to major causes of death. Because of widespread use of both beverages and limitations of prior studies, concern persists. Using Cox models (ten covariates) we studied relations in 128,934 persons to 4501 subsequent deaths. Except for slightly increased risk from acute myocardial infarction among heavier (> or = 4 cups/d) coffee users (relative risk versus nondrinkers = 1.4, 95% confidence interval = 1.0 to 1.9, P = 0.07), there was no increased risk of mortality for all deaths (relative risk per cup of coffee per day = 0.99, 95% confidence interval = 0.97 to 1.01; relative risk per cup of tea per day = 0.98, 95% confidence interval = 0.96 to 1.00) or major causes in adjusted analyses. Coffee was related to lower risk of liver cirrhosis death (relative risk per cup of coffee per day = 0.77, 95% confidence interval = 0.67 to 0.89). Use of both beverages was related to a lower risk of suicide, progressively lower at higher coffee intake (relative risk per cup of coffee per day = 0.87, 95% confidence interval = 0.77 to 0.98). We conclude that coffee and tea have no overall relation to mortality risk. If coffee increases coronary risk, this is balanced by an unexplained lower risk of other conditions, notably cirrhosis and suicide.