Facile synthesis of cucurbit[n]uril derivatives via direct functionalization:: Expanding utilization of cucurbit[n]uril
Facile synthesis of cucurbit[n]uril derivatives via direct functionalization:: Expanding utilization of cucurbit[n]uril
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DOI：
10.1021/ja036536c
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发表时间：
2003-08-27
影响因子：
15
通讯作者：
Kim, K
中科院分区：
文献类型：
--
作者：
Jon, SY;Selvapalam, N;Kim, K
葫芦脲化学中的一个长期存在的问题通过葫芦[n]脲（CB[n];n= 5−8）的第一次直接官能化得到了全羟基CB [n]，其可以进一步修饰以提供具有所需官能团和良好溶解性的定制CB[n]衍生物。CB[6]衍生物的表面修饰及其作为传感器的潜在应用。CB[6]衍生物形成可能用于蛋白质和肽药物递送的纳米球。
A long-standing problem in cucurbituril chemistry is answered through the first direct functionalization of cucurbit[n]uril (CB[n];n= 5−8)) leading to perhydroxyCB[n] which can be further modified to provide tailored CB[n] derivatives with desired functional groups and good solubility. Anchoring a CB[6] derivative on the surface and its potential application as a sensor are demonstrated. A CB[6] derivative forms nanospheres with possible use in protein and peptide drug delivery.