Visual Acuity Following Intravitreal Bevacizumab for Macular Edema Associated with Retinal Vein Occlusion
Visual Acuity Following Intravitreal Bevacizumab for Macular Edema Associated with Retinal Vein Occlusion
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DOI：
10.1007/s10384-010-0878-x
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发表时间：
2010-11-01
影响因子：
2.4
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Ota, Masafumi;Tsujikawa, Akitaka;Yoshimura, Nagahisa
目的：通过评估初始IVB后1、3和6个月的最终视力和视力之间的相关性，研究玻璃体内注射贝伐单抗（IVB）治疗视网膜静脉阻塞（RVO）相关性黄斑水肿（ME）后视力（VA）的预后因素。方法：我们回顾性研究了79例继发于RVO的ME患者的79只眼。结果：基线视力与最终视力呈显著正相关（r = 0.552，P < 0.0001）。然而，初始IVB后1、3和6个月的术后VA与最终VA的相关性更密切（分别为r = 0.793、0.816、0.893;每种情况下P < 0.0001）。此外，1个月时VA为20/40或更好的眼睛比1个月时VA差于20/40的眼睛获得了显著更好的最终VA（P < 0.0001）。结论：虽然基线VA与最终VA显著相关，但术后VA与最终VA的相关性更密切。初步IVB后不久的VA似乎可靠地预测最终的视力结果。Jpn J Ophthalmol 2010;54：555-564（C）日本眼科学会2010
Purpose: To study prognostic factors for visual acuity (VA) after intravitreal bevacizumab injection (IVB) for macular edema (ME) associated with retinal vein occlusion (RVO), by evaluating the correlation between the final VA and VA at baseline and at 1, 3, and 6 months after the initial IVB.Methods: We studied retrospectively 79 eyes of 79 patients with ME secondary to RVO treated with IVB. The correlation between the final VA and VA at each visit was studied by using Pearson's correlation coefficient.Results: Baseline VA was significantly correlated with the final VA (r = 0.552, P < 0.0001). Postoperative VA at 1, 3, and 6 months after the initial IVB, however, was even more closely correlated with the final VA (r = 0.793, 0.816, 0.893, respectively; P < 0.0001 in each case). Additionally, eyes with a VA of 20/40 or better at 1 month achieved a significantly better final VA than did eyes with a VA worse than 20/40 at 1 month (P < 0.0001). This tendency was seen also in each RVO subgroup.Conclusion: Although the baseline VA was significantly correlated with the final VA, postoperative VA was correlated even more closely with the final VA. VA shortly after the initial IVB seemed to reliably predict final visual outcome. Jpn J Ophthalmol 2010;54:555-564 (C) Japanese Ophthalmological Society 2010