Development of implantable catheter flow sensor into inside of bronchi for laboratory animal
Development of implantable catheter flow sensor into inside of bronchi for laboratory animal
复制标题
实验动物支气管内植入式导管流量传感器的研制
DOI：
10.1007/s00542-013-1924-7
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
T. Kawabe
中科院分区：
文献类型：
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作者：
M. Shikida;T. Matsuyama;T. Yamada;M. Matsushima;T. Kawabe
采用各向异性湿法腐蚀和模压工艺制备了可生物降解的透明质酸基材料金字塔形微针阵列。首先，用各向异性湿法腐蚀在硅片上制作出锥形针头作为原始母片，然后通过模压工艺将透明质酸和胶原两种可生物降解材料的混合物复制成与原始硅针相同的形状。针的高度和节距分别为0.21和0.62 mm。复制的生物降解针的尖端半径为0.005 mm。通过多次向皮肤施加载荷来评估针阵列的穿透能力。结果表明，硅和可生物降解针阵列能在100微克载荷下成功穿透硅橡胶薄膜，所研制的可生物降解针阵列能在50微克载荷下成功穿透小鼠皮肤。
A biodegradable pyramidal shaped microneedle array made of hyaluronic acid-based material was fabricated by anisotropic wet etching and a molding process. First, pyramidal shaped needles were fabricated on a Si wafer by anisotropic wet etching as an original master and then a mixture of two biodegradable materials, hyaluronic acid and a collagen, were replicated with the same shape as the original Si needle by a molding process. The height and pitch of the needle were 0.21 and 0.62 mm, respectively. The tip radius in the replicated biodegradable needle became 0.005 mm. The penetration capability of the needle arrays was evaluated by applying the load to skin multiple times. Results showed that both the Si and biodegradable needle arrays could successfully penetrate silicone rubber sheets with the applied load of 100 g. The developed biodegradable needle arrays also successfully penetrated mouse skin with the load of 50 g.