New chlorogenin hexasaccharide isolated from Agave fourcroydes with cytotoxic and cell cycle inhibitory activities
New chlorogenin hexasaccharide isolated from Agave fourcroydes with cytotoxic and cell cycle inhibitory activities
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DOI：
10.1016/j.bmc.2004.05.004
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发表时间：
2004-07-15
影响因子：
3.5
通讯作者：
Ishibashi, M
中科院分区：
文献类型：
--
作者：
Ohtsuki, T;Koyano, T;Ishibashi, M
从龙舌兰（龙舌兰科）叶子中分离出一种新的绿原素六糖 (1)。新皂苷的结构被阐明为绿原素3-O-[α-L-吡喃鼠李糖基-(1-->4)-β-D-吡喃葡萄糖基-(1-->3)-{β-D-吡喃葡萄糖基-(1-->3)-β-D-吡喃葡萄糖基-(1-->2)}-β-D-吡喃葡萄糖基-(1-->4)-β-D-吡喃半乳糖苷] (1)分析及酸水解结果。此处分离的新皂苷 (1) 以及已知的六糖 (3 和 5) 对 HeLa 细胞表现出细胞毒性，并且在浓度为 7.5 和 10 μg/mL 时，我在 G2/M 阶段表现出细胞周期抑制作用。 (C) 2004 Elsevier Ltd. 保留所有权利。
A new chlorogenin hexasaccharide (1) was isolated from leaves of Agave fourcroydes (Agavaceae). The structure of the new saponin was elucidated as chlorogenin 3-O-[alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->3)-{beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->2)}-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside] (1) by spectroscopic analysis and the result of acidic hydrolysis. The new saponin (1) as well as known hexasaccharides (3 and 5) isolated here showed cytotoxicity against HeLa cells, and I exhibited a cell cycle inhibitory effect at the G2/M stage at the concentration of 7.5 and 10 mug/mL. (C) 2004 Elsevier Ltd. All rights reserved.