Gene structure of human apolipoprotein A1.
Gene structure of human apolipoprotein A1.
复制标题
人载脂蛋白A1的基因结构。
作者：
C. Shoulders;A. Kornblihtt;B. Munro;F. Baralle
载脂蛋白A1是人血浆高密度脂蛋白（HDL）的主要多肽。载脂蛋白A1基因的结构和功能的兴趣，因为HDL水平和冠心病之间的负相关性。我们已经确定了先前分离的载脂蛋白A1基因的核苷酸序列。其编码序列被185和588碱基对的两个内含子中断。由于该基因5'端非编码区可能含有一个或多个内含子，因此无法精确定位该基因的5'端。人载脂蛋白A1有一个不寻常的前肽段非常相似，其大鼠对应。本研究结果为进一步研究载脂蛋白A1基因的结构和功能提供了重要依据。
Apolipoprotein A1 is the major polypeptide of the human plasma high density lipoprotein (HDL). The structure and function of the apo A1 gene are of interest because of the inverse correlation shown between HDL levels and coronary heart disease. We have determined the nucleotide sequence of the apo A1 gene previously isolated. Its coding sequence is interrupted by two introns of 185 and 588 base pairs. As there may be one or more introns in the 5' non coding region, the 5' end of the gene could not be precisely located. The human apo A1 has an unusual propeptide segment very similar to its rat counterpart. The data reported here provide an essential basis for future studies of structural and functional alleles of the apo A1 gene.