Involvement of Neurokinin Receptors in the Control of Pulsatile Luteinizing Hormone Secretion in Rats
Involvement of Neurokinin Receptors in the Control of Pulsatile Luteinizing Hormone Secretion in Rats
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DOI：
10.1262/jrd.11-002s
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发表时间：
2011-06-01
影响因子：
1.8
通讯作者：
Tsukamura, Hiroko
中科院分区：
文献类型：
--
作者：
Noritake, Ken-ichi;Matsuoka, Toshiki;Tsukamura, Hiroko
最近研究表明，神经激肽B（一种速激肽）与绵羊和山羊的GnRH脉冲产生有关。本研究的目的是阐明速激肽受体在大鼠LH分泌控制中的作用。为此，我们评估了CS-003（所有三种神经激肽受体（NK 1、NK 2和NK 3受体）的拮抗剂）对不同给药途径的两种性别大鼠脉冲式LH分泌的影响。CS-003经口和第三脑室给药均抑制了性腺切除动物的两种性别的LH分泌。此外，经口给予CS-003的完整雄性大鼠显示血清睾酮水平降低，这可能是由于LH分泌抑制。三种亚型特异性神经激肽受体拮抗剂中没有一种单独给药时对卵巢切除大鼠LH分泌有显著影响。本研究结果表明，神经激肽通过多种神经激肽受体在控制雄性和雌性大鼠的GnRH/LH脉冲分泌中发挥作用。
It has recently been shown that neurokinin B, a tachykinin, is associated with GnRH pulse generation in sheep and goats. The aim of the present study was to clarify the role of tachykinin receptors in the control of LH secretion in rats. To this end, we evaluated the effect of CS-003, an antagonist for all three neurokinin receptors (NK1, NK2 and NK3 receptors), on pulsatile LH secretion in both sexes of rats with different routes of administration. Both oral and third ventricular administration of CS-003 suppressed LH secretion in both sexes of gonadectomized animals. Furthermore, intact male rats with oral administration of CS-003 showed decreased serum testosterone levels, which might be due to suppressed LH secretion. None of the three subtype-specific neurokinin receptor antagonists showed a significant effect on LH secretion in ovariectomized rats when each antagonist was singly administered. The present results suggest that neurokinins play a role in the control of pulsatile GnRH/LH secretion via multiple neurokinin receptors in both male and female rats.