Hantavirus pulmonary syndrome: The first 100 US cases
Hantavirus pulmonary syndrome: The first 100 US cases
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DOI：
10.1093/infdis/173.6.1297
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发表时间：
1996-06-01
影响因子：
6.4
通讯作者：
Ksiazek, TG
中科院分区：
文献类型：
--
作者：
Khan, AS;Khabbaz, RF;Ksiazek, TG
1993年春，汉坦病毒肺综合征（HPS）在美国西南部“出现”，多机构调查导致这种新的临床实体及其病因学的快速描述，对美国首批100例病例的分析表明，该疾病分布在21个州，至少自1959年以来一直未被认识，并具有明显的春季-初夏季节性。在感染者中，54%为男性; 63%为高加索人，35%为美洲原住民，2%为非洲裔美国人。病例患者的平均年龄为34.9岁，其中8例为16岁以下的儿童或青少年。总病死率为52%。血清学、免疫组化和分子结果之间的一致性为91%。美国的HPS是由至少三种新描述的致病性汉坦病毒引起的，每种病毒都有不同的啮齿动物宿主，最近在加拿大和南美洲发现了HPS病例。对这种散发性疾病的国家监测对于进一步确定流行病学和临床谱仍然至关重要。
In the spring of 1993, hantavirus pulmonary syndrome (HPS) ''emerged'' in the southwestern United States, where a multiagency investigation led to the rapid description of this new clinical entity and its etiology, Analysis of the first 100 US cases identified showed that the disease was distributed in 21 states, had gone unrecognized since at least 1959, and had a distinct spring-early summer seasonality. Of the infected persons, 54% were male; 63% were Caucasian, 35% were Native American, and 2% were African American. The average age of case-patients was 34.9 years, and 8 were children or adolescents aged less than or equal to 16 years. The overall case-fatality rate was 52%. There was a 91% concordance among serologic, immunohistochemical, and molecular results. HPS in the United States is caused by at least three newly described pathogenic hantaviruses, each of which has a distinct rodent host, and cases of HPS have been recently recognized in Canada and South America. National surveillance of this sporadic disease remains essential for further defining the epidemiology and clinical spectrum.