Regional brain enlargement in autism: A magnetic resonance imaging study
Regional brain enlargement in autism: A magnetic resonance imaging study
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DOI：
10.1097/00004583-199604000-00020
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发表时间：
1996-04-01
影响因子：
13.3
通讯作者：
Andreasen, N
中科院分区：
文献类型：
--
作者：
Piven, J;Arndt, S;Andreasen, N
目的：探讨自闭症患者脑体积增大是由于整体还是局部脑大小差异所致，并探讨性别对脑大小和增大方式的影响。方法：采用磁共振成像和脑体积自动测量方法对35例自闭症患者和36例正常对照的脑总体积和大脑皮质体积进行检测。结果：在控制了身高和非语言智商后，作者发现总脑体积存在显著的诊断x性别效应(F=7.4；p=0.009)。重复测量方差分析表明，自闭症患者的模式或扩大(脑区x诊断)与对照组不同(F=4.88；p=.0004)。随后的性别分析显示，自闭症男性的大脑总体积显著增加，而女性则没有。对额叶大小的分析显示，自闭症受试者的颞叶、顶叶和枕叶显著增大，但额叶没有增大。结论：这些结果表明，自闭症患者的大脑大小增加，这种差异并不是泛化的，而似乎是随着特定皮质叶大小的增加而扩大的模式的结果。
Objective: To determine whether increased brain volume in autism, suggested in previous studies, is the result of general or regional brain size differences and to study the effect of gender on brain size and pattern of enlargement. Method: Total brain volume and cerebral cortical robe volumes were examined in 35 autistic and 36 comparison subjects using magnetic resonance imaging and an automated method of brain volume measurement. Results: After controlling for height and nonverbal IQ, the authors detected a significant diagnosis x gender effect (F = 7.4; p = .009) for total brain volume. A repeated-measures analysis of variance indicated that the pattern or enlargement (brain region x diagnosis) in autistic subjects differed from that in controls (F = 4.88; p = .0004). Subsequent sex-specific analysis revealed significantly increased total brain volume in autistic males but not females. Analysis of lobe sizes showed significant enlargement in autistic subjects in temporal, parietal, and occipital, but not frontal lobes. Conclusions: These results suggest that brain size is increased in autism and that differences are not generalized but appear to be the result of a pattern of enlargement with increases in the size of specific cortical lobes.