The Estrogen/Neurotrophin Connection during Neural Development: Is Co-Localization of Estrogen Receptors with the Neurotrophins and Their Receptors Biologically Relevant?
The Estrogen/Neurotrophin Connection during Neural Development: Is Co-Localization of Estrogen Receptors with the Neurotrophins and Their Receptors Biologically Relevant?
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神经发育过程中雌激素/神经营养蛋白的联系：雌激素受体与神经营养蛋白及其受体的共定位是否具有生物学相关性？
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
Toran
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文献类型：
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作者：
Toran
雌激素促进发育中的啮齿动物前脑内神经突起的生长。雌激素受体mRNA与神经营养素及其受体的mRNA共表达。雌激素可能通过直接改变生长相关基因而独立起作用，但也可能与生长因子(神经营养因子)及其受体(Trk)相互作用。雌激素也可能通过与神经营养因子调节通路的基因组串扰来促进神经营养因子的作用，这些调节通路的核终点可能是相同的雌激素反应基因。雌激素和神经生长因子(NGF)受体基因表达的差异和相互调节表明，雌激素和神经营养因子可能通过调节受体/配体的可用性或在基因转录或信号转导水平上的相互调节来影响彼此的作用。类固醇/神经营养因子的相互作用可能刺激神经元分化、存活和维持功能所需的蛋白质的合成。
Estrogen enhances neurite growth within the developing rodent forebrain. Estrogen receptor mRNA is co-expressed with the mRNA for the neurotrophins and their receptors. Estrogen may act independently by altering growth-related genes directly, but may interact additionally with growth factors (neurotrophins) and their receptors (trks). Estrogen may also act permissively to facilitate neurotrophin actions by genomic cross-talk with neurotrophin regulatory pathways whose nuclear end points may be the same estrogen-responsive genes. Differential and reciprocal regulation of estrogen and nerve growth factor (NGF) receptor gene expression by their ligands suggests that estrogen and the neurotrophins may influence each other's actions by regulating receptor/ligand availability or by reciprocal regulation at the level of gene transcription or signal transduction. Steroid/neurotrophin interactions may stimulate the synthesis of proteins required for neuronal differentiation, survival and maintenance of function.