Rasputin a decade on and more promiscuous than ever? A review of G3BPs
Rasputin a decade on and more promiscuous than ever? A review of G3BPs
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DOI：
10.1016/j.bbamcr.2018.09.001
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发表时间：
2019-03-01
影响因子：
5.1
通讯作者：
Kennedy, Derek
中科院分区：
文献类型：
--
作者：
Alam, Umber;Kennedy, Derek
ras - gtpase - activated protein (SH3 domain)-binding protein （g3bp，又称Rasputin）是一类RNA结合蛋白，通过控制mRNA的稳定性和翻译来调节基因表达以应对环境胁迫。g3bp似乎通过它们在应激颗粒中的作用促进了这种活动，它们被认为是应激颗粒的核心成分，然而，应该注意的是，并非所有的应激颗粒都含有g3bp，这似乎取决于环境应激和细胞类型。虽然g3bp在应激颗粒中的作用似乎是其主要作用之一，但数据也强烈表明它们与应激颗粒外的mrna相互作用以调节基因表达。g3bp与多种疾病有关，包括癌症进展、侵袭和转移以及病毒存活。现在有大量证据表明，靶向g3bp可以作为癌症治疗的一种形式进行探索。本文综述了近二十年来g3bp生物学领域的重要发现和进展，包括它们在RNA稳定性、细胞转录物的翻译控制、应激颗粒形成、癌症进展及其在感染过程中与病毒的相互作用等方面的作用。g3bp的一个新兴主题是它们在响应环境刺激、疾病进展和病毒感染时调节基因表达的能力，这使其成为疾病治疗的一个有趣的靶点。
Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BPs, also known as Rasputin) are a family of RNA binding proteins that regulate gene expression in response to environmental stresses by controlling mRNA stability and translation. G3BPs appear to facilitate this activity through their role in stress granules for which they are considered a core component, however, it should be noted that not all stress granules contain G3BPs and this appears to be contextual depending on the environmental stress and the cell type. Although the role of G3BPs in stress granules appears to be one of its major roles, data also strongly suggests that they interact with mRNAs outside of stress granules to regulate gene expression. G3BPs have been implicated in several diseases including cancer progression, invasion, and metastasis as well as virus survival. There is now a body of evidence that suggests targeting of G3BPs could be explored as a form of cancer therapeutic. This review discusses the important discoveries and advancements made in the field of G3BPs biology over the last two decades including their roles in RNA stability, translational control of cellular transcripts, stress granule formation, cancer progression and its interactions with viruses during infection. An emerging theme for G3BPs is their ability to regulate gene expression in response to environmental stimuli, disease progression and virus infection making it an intriguing target for disease therapies.