Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration.
Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration.
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DOI：
10.3390/ijms160819009
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发表时间：
2015-08-13
影响因子：
5.6
通讯作者：
Galindo A
中科院分区：
文献类型：
--
作者：
Herraiz I;Simón E;Gómez-Arriaga PI;Martínez-Moratalla JM;García-Burguillo A;Jiménez EA;Galindo A
胎盘功能障碍涉及一组产科条件，包括先兆子痫，宫内生长受限，胎盘早剥。由于诊断标准仍然基于非特异性体征和症状，因此及时准确地识别它们往往是一项挑战。血管生成相关因子（sFlt-1/PlGF）在胎盘功能障碍的潜在病理生理中的作用的发现，考虑到血管生成相关的生物标志物并不针对任何特定的胎盘功能不全相关疾病，标志着改善其早期诊断和预后评估的重要一步。然而，sFlt-1/PlGF尚未被确定为大多数指南的一部分。我们将回顾目前关于sFlt-1/PlGF临床应用的证据，并提出一个新的临床整合方案。
Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to any particular placental insufficiency-related disease, has marked an important step for improving their early diagnosis and prognosis assessment. However, sFlt-1/PlGF has not been yet established as a part of most guidelines. We will review the current evidence on the clinical utility of sFlt-1/PlGF and propose a new protocol for its clinical integration.