Novel coronavirus infection in children outside of Wuhan, China
Novel coronavirus infection in children outside of Wuhan, China
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中国武汉以外儿童感染新型冠状病毒
DOI：
10.1002/ppul.24762
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发表时间：
2020-04-07
影响因子：
3.1
通讯作者：
Peng, Hong
中科院分区：
文献类型：
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作者：
Shen, Qinxue;Guo, Wei;Peng, Hong
背景自2019年12月8日以来，2019冠状病毒病（COVID-19）疫情迅速蔓延，但有关COVID-19儿童的信息有限。 方法本回顾性单中心研究在中国湖南省长沙市公共卫生临床中心进行。我们确定了 2019 年 1 月 8 日至 2020 年 2 月 19 日期间长沙市所有被诊断患有 COVID-19 的住院儿童。收集并分析这些儿童的流行病学和临床数据。结果追踪至2020年2月26日。 结果 截至2020年2月19日，长沙市已确诊9名儿童患者感染2019-nCoV。 6名儿童有家庭接触史，能够提供与确诊2019-nCoV感染者密切接触的确切日期，其中潜伏期中位数为7.5天。 9名儿童初期症状较轻，包括发烧（3/9）、腹泻（2/9）、咳嗽（1/9）、喉咙痛（1/9），其中两人无症状。其中两名入组患者的胸部计算机断层扫描显示有小毛玻璃样混浊。截至 2 月 26 日，6 名患者 2019-nCoV RT-PCR 呈阴性并已出院。从暴露到 RT-PCR 呈阴性的中位时间为 14 天。结论 儿童新型冠状病毒感染的临床症状不典型，并且表现出比青少年和成人患者更不侵袭性的临床病程。有家族聚集性或有确诊家庭成员的儿童应报告，以确保及时诊断。
Background Since December 8, 2019, an epidemic of coronavirus disease 2019 (COVID-19) has spread rapidly, but information about children with COVID-19 is limited.Methods This retrospective and the single-center study were done at the Public Health Clinic Center of Changsha, Hunan, China. We identified all hospitalized children diagnosed with COVID-19 between January 8, 2019 and February 19, 2020, in Changsha. Epidemiological and clinical data of these children were collected and analyzed. Outcomes were followed until February 26th, 2020.Results By February 19, 2020, nine pediatric patients were identified as having 2019-nCoV infection in Changsha. Six children had a family exposure and could provide the exact dates of close contact with someone who was confirmed to have 2019-nCoV infection, among whom the median incubation period was 7.5 days. The initial symptoms of the nine children were mild, including fever (3/9), diarrhea (2/9), cough (1/9), and sore throat (1/9), two had no symptoms. Two of the enrolled patients showed small ground-glass opacity of chest computed tomography scan. As of February 26, six patients had a negative RT-PCR for 2019-nCoV and were discharged. The median time from exposure to a negative RT-PCR was 14 days.Conclusions The clinical symptoms of the new coronavirus infection in children were not typical and showed a less aggressive clinical course than teenage and adult patients. Children who have a familial clustering or have a family member with a definite diagnosis should be reported to ensure a timely diagnosis.