Trafficking of immune cells in the central nervous system
Trafficking of immune cells in the central nervous system
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DOI：
10.1172/jci41911
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发表时间：
2010-05-01
影响因子：
15.9
通讯作者：
Hunter, Christopher A.
中科院分区：
文献类型：
--
作者：
Wilson, Emma H.;Weninger, Wolfgang;Hunter, Christopher A.
中枢神经系统是一个免疫特权环境，但对多种病原体的局部控制取决于免疫细胞进入该部位并在其中运作的能力。然而，与中枢神经系统相关的不同解剖部位（即脑膜、脑脊液和实质）的炎症也可能是有害的。因此，控制淋巴细胞在大脑内的进入和迁移对于调节保护性和病理性反应至关重要。在这篇综述中，重点介绍了一些最新进展，这些进展为调节白细胞进入大脑和在大脑内运动的过程提供了新的见解。
The CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct anatomical sites (i.e., meninges, cerebrospinal fluid, and parenchyma) associated with the CNS can also be deleterious. Therefore, control of lymphocyte entry and migration within the brain is vital to regulate protective and pathological responses. In this review, several recent advances are highlighted that provide new insights into the processes that regulate leukocyte access to, and movement within, the brain.