Extraocular muscle sampled volume in Graves' orbitopathy using 3-T fast spin-echo MRI with iterative decomposition of water and fat sequences.
Extraocular muscle sampled volume in Graves' orbitopathy using 3-T fast spin-echo MRI with iterative decomposition of water and fat sequences.
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DOI：
10.1177/2058460118780892
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发表时间：
2018-06
影响因子：
1.1
通讯作者：
Panzironi G
中科院分区：
文献类型：
--
作者：
Garau LM;Guerrieri D;De Cristofaro F;Bruscolini A;Panzironi G
目前用于测量眼外肌（EOM）体积增大的磁共振成像（MRI）技术并不理想地适合格雷夫斯眼病（GO）的常规随访，因为在肌腱附着处分割肌肉的困难使研究方案变得复杂和延长。测量眼外肌采样体积（SV）并评估其与眼球突出的相关性。共有37例新诊断的GO患者接受了3-T MRI扫描，采用水和脂肪迭代分解（IDEAL）序列，有或没有增强。在每例患者中，使用多边形选择工具分割EOM切片上的三个最大连续冠状横截面积（CSA），然后求和以计算EOM-SV。用Hertel指数（HI）评价眼球突出。用Pearson相关系数和单因素回归分析评价HI值与EOM-SV和EOM-CSA的关系。计算观察者间和观察者内变异性。HI与EOM-SV的相关性（P < 0.001; r = 0.712，r2 = 0.507）强于与EOM-CSA的相关性（P < 0.001; r = 0.645，r2 = 0.329）。组内相关系数表明观察者间一致性较高（0.998）。重复测量之间的标准偏差为1.9- 5.3%。IDEAL序列允许在非造影和造影增强扫描上测量EOM-SV。EOM-SV比EOM-CSA更准确地预测眼球突出。EOM-SV的测量具有实用性和重复性。可以假设EOM-SV变化为3.5-8.3%，以反映真实的体积变化。
Current magnetic resonance imaging (MRI) techniques for measuring extraocular muscle (EOM) volume enlargement are not ideally suited for routine follow-up of Graves’ ophthalmopathy (GO) because the difficulty of segmenting the muscles at the tendon insertion complicates and lengthens the study protocol. To measure the EOM sampled volume (SV) and assess its correlation with proptosis. A total of 37 patients with newly diagnosed GO underwent 3-T MRI scanning with iterative decomposition of water and fat (IDEAL) sequences with and without contrast enhancement. In each patient, the three largest contiguous coronal cross-sectional areas (CSA) on the EOM slices were segmented using a polygon selection tool and then summed to compute the EOM-SV. Proptosis was evaluated with the Hertel index (HI). The relationships between the HI value and EOM-SV and between HI and EOM-CSA were compared and assessed with Pearson’s correlation coefficient and the univariate regression coefficient. Inter-observer and intra-observer variability were calculated. HI showed a stronger correlation with EOM-SV (P < 0.001; r = 0.712, r2 = 0.507) than with EOM-CSA (P < 0.001; r = 0.645 and r2 = 0.329). The intraclass correlation coefficient indicated that the inter-observer agreement was high (0.998). The standard deviation between repeated measurements was 1.9–5.3%. IDEAL sequences allow for the measurement EOM-SV both on non-contrast and contrast-enhanced scans. EOM-SV predicts proptosis more accurately than does EOM-CSA. The measurement of EOM-SV is practical and reproducible. EOM-SV changes of 3.5–8.3% can be assumed to reflect true volume changes.