Vivosorb®, Bio-Gide®, and Gore-Tex® as barrier membranes in rat mandibular defects:: an evaluation by microradiography and micro-CT
Vivosorb®, Bio-Gide®, and Gore-Tex® as barrier membranes in rat mandibular defects:: an evaluation by microradiography and micro-CT
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DOI：
10.1111/j.1600-0501.2007.01511.x
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发表时间：
2008-05-01
影响因子：
4.3
通讯作者：
Bos, Ruud R. M.
中科院分区：
文献类型：
--
作者：
Gielkens, Pepijn F. M.;Schortinghuis, Jurjen;Bos, Ruud R. M.
目的：研究聚乳酸-己内酯(PDLLCL)可降解合成屏障膜(Vivosorb(R))在种植牙科中的应用，并与胶原蛋白和膨体聚四氟乙烯(EPTFE)膜进行比较。材料和方法：雄性SD大鼠192只，垂直下颌角造成标准的5 mm圆形缺损。通过死后显微放射摄影和微CT(MU CT)成像评价新骨形成情况。4组(对照组、PDLLCL、胶原蛋白、ePTFE)在3个时间间隔(2、4、12周)进行评估。在膜组中，缺损处被覆盖；在对照组，缺损处未被覆盖。结果：130例标本死后显微放射学检查可检出新骨形成，112例标本经多层螺旋CT扫描可检出新骨形成。当下颌骨缺损处被一层膜覆盖时，骨形成在12周内逐渐形成。总体而言，胶原和ePTFE膜下的骨形成多于PDLLCL膜下的骨形成。结论：与未覆盖的下颌骨缺损区相比，PDLLCL膜覆盖的缺损区可以观察到实质性的骨愈合。然而，PDLLCL覆盖的缺损区的骨形成倾向于少于胶原或ePTFE覆盖的缺损区。在12周时，PDLLCL样本的高度变异可能是由于与胶原相比，该膜与骨的粘附性中等所致。这些结果表明，PDLLCL膜的性能有待进一步优化。
Objectives: The objectives of this study were to determine whether a new degradable synthetic barrier membrane (Vivosorb (R)) composed of poly(DL-lactide-epsilon-caprolactone) (PDLLCL) can be useful in implant dentistry and to compare it with collagen and expanded polytetrafluoroethylene (ePTFE) membranes.Material and methods: In 192 male Sprague-Dawley rats, a standardized 5 mm circular defect was created through the right angle of the mandible. New bone formation was evaluated by post-mortem microradiography and micro-CT (mu CT) imaging. Four groups (control, PDLLCL, collagen, ePTFE) were evaluated at three time intervals (2, 4, and 12 weeks). In the membrane groups the defects were covered; in the control group the defects were left uncovered. Data were analysed using a multiple regression model.Results: New bone formation could be detected by post-mortem microradiography in 130 samples and by mu CT imaging in 112 samples. Bone formation was progressive in 12 weeks, when the mandibular defect was covered with a membrane. Overall, more bone formation was observed underneath the collagen and ePTFE membranes than the PDLLCL membranes.Conclusions: In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a PDLLCL membrane. However, bone formation in PDLLCL-covered defects tended to be less than in the defects covered with collagen or ePTFE. The high variation in the PDLLCL samples at 12 weeks may be caused by the moderate adherence of this membrane to bone compared with collagen. These results indicate that further study is needed to optimize the properties of PDLLCL membranes.