Proteoglycan gene expression in rat liver after partial hepatectomy
Proteoglycan gene expression in rat liver after partial hepatectomy
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DOI：
10.1006/bbrc.1996.1718
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发表时间：
1996-11-21
影响因子：
3.1
通讯作者：
Thorgeirsson, SS
中科院分区：
文献类型：
--
作者：
Gallai, M;Sebestyen, A;Thorgeirsson, SS
Liver regeneration is regulated by several factors. Among these extracellular matrix plays a crucial role in the restoration of normal structure. Proteoglycans are major component of extracellular matrix and they are able to bind growth factors implicated in liver growth. Wa studied syndecan, perlecan, fibroglycan, and decorin expression after partial hepatectomy In rats by Northern blot analysis. A strong early upregulation was observed at 30 min in decorin expression which was followed by the first syndecan and perlecan peaks at 2 and 4 hours after hepatectomy. Ar 2 ? hours, which is the peak oi. hepatocyte DNA synthesis, all these three proteoglycans had elevated steady state transcript level. Fibroglycan message decreased after partial hepatectomy anti remained low during the experimental period. The different expression pattern of the proteoglycans suggests that these extracellular matrix components may selectively influence the regeneration process. (C) 1996 Academic Press, Inc.
