Enriching adult male rats prior to traumatic brain injury does not attenuate neurobehavioral or histological deficits.
Enriching adult male rats prior to traumatic brain injury does not attenuate neurobehavioral or histological deficits.
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在创伤性脑损伤之前丰富成年雄性大鼠并不能减轻神经行为或组织学缺陷。
DOI：
10.1016/j.brainres.2023.148314
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发表时间：
2023
期刊：
影响因子：
2.9
通讯作者：
Kline,AnthonyE
中科院分区：
文献类型：
--
作者：
Moschonas,EleniH;Niesman,PeterJ;Vozzella,VincentJ;Bittner,RachelA;Brennan,ConnorJ;Cheng,JeffreyP;Bondi,CorinaO;Kline,AnthonyE
环境丰富（EE）赋予显着增加神经行为和认知恢复，并减少创伤性脑损伤（TBI）的各种模型中的组织损伤。然而，尽管EE的普遍性，很少有人知道它的预防潜力。因此，本研究的目标是确定是否丰富的大鼠之前，一个控制的皮质影响发挥保护作用的衰减损伤诱导的神经行为和组织学缺陷相对于大鼠没有事先EE。该假设是，富集之前TBI将是保护。在EE或标准（STD）饲养两周后，麻醉的成年雄性大鼠接受受控的皮质撞击（以4 m/s的速度变形2.8 mm）或假损伤，然后置于EE或STD条件下。分别在术后第1-5天和第14-18天评估运动（横梁行走）和认知（空间学习）表现。在第21天定量皮质病变体积。在TBI之前被安置在STD条件下并接受损伤后EE的组在运动、认知和组织学结果方面显著优于STD条件下的两个组，无论是否接受了损伤前EE（p< 0.05）。TBI后，两个性病饲养组之间在任何终点上都没有发现差异，这表明TBI前富集大鼠不会减轻神经行为或组织学缺陷，因此不支持该假设。
Environmental enrichment (EE) confers significant increases in neurobehavioral and cognitive recovery and decreases histological damage in various models of traumatic brain injury (TBI). However, despite EE’s pervasiveness, little is known regarding its prophylactic potential. Thus, the goal of the current study was to determine whether enriching rats prior to a controlled cortical impact exerts protection as evidenced by attenuated injury-induced neurobehavioral and histological deficits relative to rats without prior EE. The hypothesis was that enrichment prior to TBI would be protective. After two weeks of EE or standard (STD) housing, anesthetized adult male rats received either a controlled cortical impact (2.8 mm deformation at 4 m/s) or sham injury and then were placed in EE or STD conditions. Motor (beam-walk) and cognitive (spatial learning) performance were assessed on post-operative days 1–5 and 14–18, respectively. Cortical lesion volume was quantified on day 21. The group that was housed in STD conditions before TBI and received post-injury EE performed significantly better in motor, cognitive, and histological outcomes vs. both groups in STD conditions regardless of whether having received pre-injury EE or not (p< 0.05). That no differences in any endpoint were revealed between the two STD-housed groups after TBI suggests that enriching rats prior to TBI does not attenuate neurobehavioral or histological deficits and therefore does not support the hypothesis.