Interrupted Pummerer Reaction in Latent/Active Glycosylation
Interrupted Pummerer Reaction in Latent/Active Glycosylation
复制标题
潜在/活性糖基化中的 Pummerer 反应中断
作者：
Meng L.;Zeng J.;Wan Q.
摘要潜伏/主动糖基化策略是寡糖快速组装的有效方法。我们最近开发了新的OPTB/OPSB和SPTB/SPSB糖苷作为两对潜在/活性糖基供体。活性OPSB和SPSB糖基供体通过中断的Pummerer反应机制被Tf 2 O有效激活。本文介绍了这些新的糖基化方法的设计、发展、机理研究和应用。1引言2构思3 OPSB和SPSB糖苷的合成4底物范围5在天然产物合成中的应用6结论
Abstract A latent/active glycosylation strategy is efficient for rapid assembly of oligosaccharides. We recently developed novel OPTB/OPSB and SPTB/SPSB glycosides as two pairs of latent/active glycosyl donors. The active OPSB and SPSB glycosyl donors are efficiently activated by Tf2O via an interrupted Pummerer reaction mechanism. In this account, the design, developments, mechanism studies and applications of these new glycosylation methodologies are described. 1 Introduction 2 Conceiving Ideas 3 Synthesis of OPSB and SPSB Glycosides 4 Substrate Scope 5 Application in the Synthesis of Natural Products 6 Conclusion