The absence of corneal toxicity with low-level topical anesthesia.
The absence of corneal toxicity with low-level topical anesthesia.
复制标题
低度局部麻醉不会产生角膜毒性。
DOI：
10.1016/s0002-9394(14)76038-6
复制
发表时间：
1985
影响因子：
4.2
通讯作者：
Singh,T
中科院分区：
文献类型：
--
作者：
Maurice,DM;Singh,T
By means of an osmotic pump we infused 0.3% proparacaine solution continuously into the central stroma of a rabbit cornea. An area of anesthesia about 6 mm in diameter was maintained for several days. The epithelium remained unaffected and healed normally where it was scraped away in the anesthetic area. Similarly, the repeated instillation into the rabbit's eye of 0.05% proparacaine eyedrops at ten-minute intervals throughout the day resulted in continual anesthesia without signs of epithelial dystrophy. It seems that the toxic level of proparacaine is above that required for anesthesia.
