The chiaroscuro stem cell: a unified stem cell theory
The chiaroscuro stem cell: a unified stem cell theory
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DOI：
10.1182/blood-2002-04-1246
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发表时间：
2002-12-15
期刊：
影响因子：
20.3
通讯作者：
Lambert, JF
中科院分区：
文献类型：
--
作者：
Quesenberry, PJ;Colvin, GA;Lambert, JF
造血在本质上被认为是分级的，但最近的数据表明，这个系统没有分级，实际上在功能上是可塑性的。现有数据表明，植入和祖细胞表型与细胞周期传递成反比，基因表达也有很大差异。这些观察表明，不存在祖细胞/干细胞层级，而是一个可逆的连续体。反过来，这可能依赖于染色质和基因表达随细胞周期的变化。如果这些原始骨髓细胞的表型通过周期传递从可植入干细胞转变为祖细胞，然后再转变回可植入干细胞，那么这表明可移植干细胞的身份可能在非同步化的骨髓细胞群中被部分掩盖。一般模型表明，骨髓细胞可以不断改变其表面受体的表达，从而在细胞周期的不同时间点对外部刺激做出不同的反应。
Hematopoiesis has been considered hierarchical in nature, but recent data suggest that the system is not hierarchical and is, in fact, quite functionally plastic. Existing data indicate that, engraftment and progenitor phenotypes vary inversely with cell cycle transit and that gene expression also varies widely. These observations suggest that there is no progenitor/stem cell hierarchy, but rather a reversible continuum. This may, in turn, be dependent on shifting chromatin and gene expression with cell cycle transit. If the phenotype of these primitive marrow cells changes from engraftable stem cell to progenitor and back to engraftable stem cell with cycle transit, then this suggests that the identity of the engraftable stem cell may be partially masked in nonsynchronized marrow cell populations. A general model indicates a marrow cell that can continually change its surface receptor expression and thus responds to external stimuli differently at different points in the cell cycle.