Nutritional management contributes to improvement in minimal hepatic encephalopathy and quality of life in patients with liver cirrhosis: A preliminary, prospective, open-label study
Nutritional management contributes to improvement in minimal hepatic encephalopathy and quality of life in patients with liver cirrhosis: A preliminary, prospective, open-label study
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DOI：
10.1111/j.1872-034x.2012.01092.x
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发表时间：
2013-05-01
影响因子：
4.2
通讯作者：
Okita, Kiwamu
中科院分区：
文献类型：
--
作者：
Kato, Akinobu;Tanaka, Hiroto;Okita, Kiwamu
目的轻度肝性脑病（MHE）患者的问题包括跌倒和驾驶技能缺陷等发作，而没有任何神经生理功能障碍的认识。MHE患者也更容易发展为显性肝性脑病。然而，目前还没有任何涉及营养管理的MHE干预策略。我们进行了一项初步研究，以调查MHE阳性的比例和营养管理对MHE的影响。方法对病毒性肝硬化合并神经心理检查异常的患者进行分析。营养师定期进行营养咨询，建议每天摄入3035千卡热量和1.01.5克蛋白质/公斤理想体重。主要终点是评估从MHE中恢复的患者比例。次要终点是评估患者生活质量（QOL）的改善。结果106例患者中32例（30.1%）确诊为MHE。19名患者参加了这项研究。19例患者中11例在4周后变为非mhe， 19例患者中13例(68.4%，P
Aim Problems in patients with minimal hepatic encephalopathy (MHE) include episodes such as falls and deficient driving skills, without any recognition of neurophysiological dysfunction. Patients with MHE are also more likely to develop overt hepatic encephalopathy. However, there is not yet any interventional strategy for MHE involving nutritional management. We conducted a preliminary study to investigate the proportion of positive MHE and the effects of nutritional management on MHE. Methods Patients with viral liver cirrhosis and abnormal neuropsychological tests were included. Nutritional consultations were conducted periodically by a dietitian, who recommended 3035kcal with 1.01.5g of protein/kg of ideal bodyweight/day. The primary end-point was to evaluate the proportion of patients who recovered from MHE. The secondary end-point was to evaluate the improvement in the patients' quality of life (QOL). Results Thirty-two (30.1%) of 106 patients were diagnosed with MHE. Nineteen patients were enrolled in the study. Eleven of 19 patients became non-MHE after 4weeks, and 13 of 19 patients (68.4%, P