In Situ Production of Ag/Polymer Asymmetric Nanoparticles via a Powerful Light-Driven Technique
In Situ Production of Ag/Polymer Asymmetric Nanoparticles via a Powerful Light-Driven Technique
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DOI：
10.1021/jacs.9b10205
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发表时间：
2019-12-18
影响因子：
15
通讯作者：
Wooley, Karen L.
中科院分区：
文献类型：
--
作者：
Li, Richen;Wang, Hai;Wooley, Karen L.
作为一种快速、可控、易转移的制备抗菌纳米颗粒体系的方法，我们开发了一种一步光驱动的方法，直接从均匀的Ag/聚合物混合物制备不对称的无机-有机杂化纳米颗粒（NPs）。设计并合成了一种由聚环氧乙烷（PEO）、羧酸官能化的聚磷酸酯（PPE）和聚（L-丙交酯）（PLLA）组成的两亲性三嵌段聚合物，用于构建生物相容性纳米粒。出乎意料的是，随后通过简单地将银阳离子加载到聚合物胶束中并通过离心纯化来获得雪人状不对称纳米结构。随着对不对称NP形成的化学性质的理解，通过施加UV照射开发了可控的制备策略。通过透射电子显微镜观察到的形态转变，在紫外线照射时间，从小银纳米粒子分布在胶束内的雪人般的不对称的纳米粒子，其具有独特的两阶段银释放曲线的潜在的抗菌应用的希望。
As a rapid, controllable, and easily transferrable approach to the preparation of antimicrobial nanoparticle systems, a one-step, light-driven procedure was developed to produce asymmetric hybrid inorganic-organic nanoparticles (NPs) directly from a homogeneous Ag/polymer mixture. An amphiphilic triblock polymer was designed and synthesized to build biocompatible NPs, consisting of poly(ethylene oxide) (PEO), carboxylic acid-functionalized polyphosphoester (PPE), and poly(L-lactide) (PLLA). Unexpectedly, snowman-like asymmetric nanostructures were subsequently obtained by simply loading silver cations into the polymeric micelles together with purification via centrifugation. With an understanding of the chemistry of the asymmetric NP formation, a controllable preparation strategy was developed by applying UV irradiation. A morphology transition was observed by transmission electron microscopy over the UV irradiation time, from small silver NPs distributed inside the micelles into snowman-like asymmetric NPs, which hold promise for potential antimicrobial applications with their unique two-stage silver release profiles.