The Dynamic Duo-Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases.
The Dynamic Duo-Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases.
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风湿病中的动态双炎症 M1 巨噬细胞和 Th17 细胞。
DOI：
10.13188/2334-2846.1000002
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发表时间：
2013-11-01
期刊：
影响因子：
--
通讯作者：
Mountz JD
中科院分区：
文献类型：
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作者：
Li J;Hsu HC;Mountz JD
类风湿性关节炎（RA）患者的滑膜组织富含巨噬细胞和T淋巴细胞，它们是RA发病机制中的两个核心角色。骨髓细胞和 T 细胞之间的相互作用对于滑膜炎症过程的启动和进展至关重要。随着我们对这两种细胞类型如何参与免疫反应调节的理解迅速发展，RA 正在成为研究细胞间相互作用的理想疾病模型，从而引入旨在破坏这些过程的新型生物制剂。本综述将讨论风湿性疾病中 IL-23+ 炎症巨噬细胞和 IL-17+ GM-CSF+ CD4 T 细胞之间的双向相互作用，以及在此背景下通过诱导细胞凋亡的潜在抗风湿策略。
The synovial tissue of Rheumatoid Arthritis (RA) patients is enriched with macrophages and T lymphocytes which are two central players in the pathogenesis of RA. Interaction between myeloid cells and T cells are essential for the initiation and progression of the inflammatory processes in the synovium. With the rapid evolution of our understanding of how these two cell types are involved in the regulation of immune responses, RA is emerging as an ideal disease model for investigating the cell-cell interactions and consequently introducing novel biologic agents that are designed to disrupt these processes. This review will discuss the bidirectional interaction between the IL-23+ inflammatory macrophages and IL-17+ GM-CSF+ CD4 T cells in rheumatic diseases as well as potential antirheumatic strategies via apoptosis induction in this context.