Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former New Zealand trichlorophenol workers
Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former New Zealand trichlorophenol workers
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DOI：
10.1016/j.chemosphere.2009.05.037
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发表时间：
2009-09-01
期刊：
影响因子：
8.8
通讯作者：
Bodner, Kenneth
中科院分区：
文献类型：
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作者：
Collins, James J.;Wilken, Michael;Bodner, Kenneth
这项研究检测了346名新西兰雇员的血清中2，3，7，8-取代的氯代二恶英和呋喃以及15种多氯联苯的水平，这些雇员在一个生产2，4，5-三氯苯酚（TCP）和2，4，5-三氯苯氧基乙酸（2，4，5-T）的工厂工作。有潜在TCP或2，4，5-T暴露的参与者的平均脂质调整2，3，7，8-四氯二苯并-p-二恶英（2，3，7，8-TCDD）水平为9.9 ng kg（-1）脂质，而在现场没有暴露的工人为4.9 ng kg（-1）。在暴露的工人中，我们发现了不同部门和职责的2，3，7，8-TCDD水平差异的证据。参与意外释放的工人的2，3，7，8-四氯二苯并对二恶英平均水平最高，为37.9纳克/千克（-1），其次是三氯苯酚工厂的工人，为23.4纳克/千克（-1）。在建筑、维修、机械和运输行业可能间歇性接触2，3，7，8-四氯二苯并对二恶英的工人的2，3，7，8-四氯二苯并对二恶英水平高于新西兰的背景水平3.9纳克/千克（-1），表明他们在工作场所接触过这种物质。在工作经历表明没有2，3，7，8-TCDD暴露的参与者中，我们观察到一些人的2，3，7，8-TCDD水平高于背景水平。然而，在大多数情况下，这些工人报告的工作场所接触情况未记录在其工作记录中，或在工厂外从事可能接触2，3，7，8-四氯二苯并对二恶英的其他工作。所有其他二恶英，呋喃和多氯联苯水平之间的接触和未接触的工人相似。(C)2009爱思唯尔有限公司版权所有。
This study examined serum levels of 2,3,7,8-substituted chlorinated dioxins and furans, and 15 PCBs for 346 New Zealand employees who worked at a site that manufactured 2,4,5-trichlorophenol (TCP) and 2,4,5-trichlorophenoxy acetic acid (2,4,5-T). Participants with potential TCP or 2,4,5-T exposures had mean lipid-adjusted 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) levels of 9.9 ng kg(-1) lipid compared to 4.9 ng kg(-1) for workers with no exposure at the site. Among exposed workers, we found evidence of differences in 2,3,7,8-TCDD levels by department and duties. Workers involved in an accidental release had the highest mean 2,3,7,8-TCDD levels, 37.9 ng kg(-1), followed by workers in the trichlorophenol plant, 23.4 ng kg(-1). Workers with potential intermittent exposures to 2,3.7,8-TCDD in construction, maintenance, mechanics, and transport had 2,3,7,8-TCDD levels above New Zealand background levels of 3.9 ng kg(-1), indicating workplace exposures. Among participants with work history indicating no 2,3,7,8-TCDD exposures, we observed some individuals with 2,3,7,8-TCDD levels above background levels. However, in most cases, these workers reported workplace exposures not recorded on their work histories or held other jobs with the potential for 2,3,7,8-TCDD exposures outside the plant. All other dioxin, furan, and PCB levels were similar among the exposed and unexposed workers. (C) 2009 Elsevier Ltd. All rights reserved.