Novel concentrated water‐in‐oil emulsions based on a non‐ionic silicone surfactant: Appealing application properties and tuneable viscoelasticity
Novel concentrated water‐in‐oil emulsions based on a non‐ionic silicone surfactant: Appealing application properties and tuneable viscoelasticity
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DOI：
10.1016/j.ejpb.2017.08.003
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发表时间：
2017-11
影响因子：
4.9
通讯作者：
L. Binder;Johannes Jatschka;D. Baurecht;M. Wirth;C. Valenta
中科院分区：
文献类型：
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作者：
L. Binder;Johannes Jatschka;D. Baurecht;M. Wirth;C. Valenta
硅酮辅料是广泛用于局部制剂的无刺激性成分。在本研究中，开发了具有高含水量的创新油包水乳液，该乳液由非离子型有机硅表面活性剂稳定。考察了配方组成对其性能和稳定性的影响。这是可能的，以制备高度稳定的乳液的水体积分数高达80%。乳液表现出理想的应用性能，如非粘性和冷却质量。粘度依赖于水的分数被发现，这提供了机会，以创建具有微调的流变学properties的乳液。此外，它可以在皮肤的研究表明，thein体外释放的亲水性模型药物的油相的配置的影响。使用胶带剥离和ATR-FTIR实验监测了硅酮表面活性剂和其他部署的添加剂的渗透，结果表明化合物保留在角质层的表层，从而最大限度地降低了皮肤刺激的风险。
Silicone excipients are non-irritating ingredients that are extensively used in topical formulations. In the present study, innovative water-in-oil emulsions with a high water content stabilised by a non-ionic silicone surfactant were developed. Effects of formulation composition on its properties and stability were investigated. It was possible to prepare highly stable emulsions with a water volume fraction of up to 80%. The emulsions exhibited desirable application properties such as non-sticky and cooling qualities. A dependency of the viscosity on the water fraction was found; this offers the opportunity to create emulsions with fine-tuned rheological properties.Furthermore, it could be shown in skin studies that thein vitrorelease of a hydrophilic model drug is influenced by the configuration of the oil phase. The penetration of the silicone surfactant and the other deployed additives was monitored using combined tape stripping and ATR-FTIR experiments, revealing that the compounds remain in the superficial layers of the stratum corneum, thus minimising the risk for skin irritation.