90K (Mac-2 BP) and galectins in tumor progression and metastasis
90K (Mac-2 BP) and galectins in tumor progression and metastasis
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DOI：
10.1023/b:glyc.0000014085.00706.d4
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Iacobelli, S
中科院分区：
文献类型：
--
作者：
Grassadonia, A;Tinari, N;Iacobelli, S
Galectins及其配体与细胞转化和癌症转移有关，并被发现具有预后价值。Mac-2BP，也被称为90K，是一种高度糖化的分泌蛋白，在人类癌症中被广泛研究，它与Galectin-1、Galectin-3和Galectin-7结合。在不同类型的恶性肿瘤患者中，90K的高表达水平与较短的生存期、转移的发生或对化疗的反应降低有关。90K和Galectins在癌症中的预后意义的潜在机制尚不清楚，尽管它们可能与这些蛋白质相互作用的能力有关，并在一定程度上调节细胞与细胞和细胞基质的黏附和凋亡。由此产生的情况甚至更加复杂，因为已经有数据表明，所有这些蛋白质可能与患者的积极或消极结果有关。推测在肿瘤转移的不同阶段，不同功能重叠或相反的Galectins和Galectin配体在不同肿瘤中的表达可能在肿瘤进展中起关键作用。
Galectins and their ligands have been implicated in cell transformation and cancer metastasis, and found to have prognostic value. Mac-2 BP, also known as 90K, is a highly glycosylated, secreted protein extensively studied in human cancer, which binds galectin-1, galectin-3 and galectin-7. High expression levels of 90K are associated with a shorter survival, the occurrence of metastasis or a reduced response to chemotherapy in patients with different types of malignancy. The mechanisms underlying the prognostic significance of 90K and galectins in cancer are far from being understood, although they may be related to the ability of these proteins to interact and, to some extent, modulate cell-cell and cell-matrix adhesion and apoptosis. The resulting scenario is even more complex, as data have been presented that all these proteins might be associated with either a positive or a negative outcome of the patients. It is hypothesised that different galectins and galectin ligands with overlapping or opposite functions, expressed in different tumors during the different steps of the metastatic cascade might play a crucial role in tumor progression.