Development of the larval somatic musculature
Development of the larval somatic musculature
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DOI：
10.1007/0-387-32963-3_7
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Baylies, Mary
中科院分区：
文献类型：
--
作者：
Carmena, Ana;Baylies, Mary
果蝇幼虫的躯体肌肉组织每半节有30条肌纤维，呈高度定型的排列。每一块肌肉都有一套独特的特性：大小、形状、方向、与表皮的附着和特定的神经支配。这些品质使每个肌纤维成为图案中的独特元素。在这一章中，我们将回顾迄今为止关于肌肉如何获得其特定身份的已知信息。我们讨论的机制，肌肉创始人细胞和融合能力的成肌细胞的规格，以及如何这两种类型的成肌细胞有助于每个幼虫肌肉的最终模式。虽然大量的证据支持创始人细胞在赋予特定的肌肉身份中的关键作用，但融合成肌细胞在肌肉形态发生过程中的功能仍然是该领域未来研究的一个悬而未决的问题。
The larval somatic musculature ofDrosophilais arranged in a highly stereotyped pattern of 30 muscle fibers per hemisegment. Each muscle possesses a distinctive set of properties: size, shape, orientation, attachments to the epidermis and specific innervation. These qualities make each myofiber a unique element within the pattern. In this chapter we review what is known to date about how a muscle acquires its particular identity. We discuss the mechanisms that underlie the specification of muscle founder cells and fusion-competent myoblasts and how both types of myoblasts contribute to the final pattern of each larval muscle. While a body of evidence supports a crucial role for founder cells in conferring particular muscle identities, the function of fusion-competent myoblasts during muscle morphogenesis remains an open question for future investigation in the field.