Pediatric Epilepsy Surgery: The Prognostic Value of Central Nervous System Comorbidities in Patients and their Families.
Pediatric Epilepsy Surgery: The Prognostic Value of Central Nervous System Comorbidities in Patients and their Families.
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DOI：
10.1177/0883073816685653
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发表时间：
2017-04
影响因子：
1.9
通讯作者：
Greiner HM
中科院分区：
文献类型：
--
作者：
Qualmann KJ;Spaeth CG;Myers MF;Horn PS;Holland K;Mangano FT;Greiner HM
癫痫患者存在中枢神经系统（CNS）合并症。在患者队列中，这些合并症中的一些与不良手术结果相关。作者试图在横断面分析中确定小儿癫痫手术患者及其家庭合并症的患病率是否与长期癫痫发作结果相关。对52例患者的癫痫、多动症、焦虑、自闭症、双相情感障碍、认知障碍、抑郁、偏头痛和运动障碍家族史与手术结果进行了三代谱系比较。将受影响的患者和亲属的比例与一般人群的合并率和患者最近的癫痫发作结果分类进行比较。患者及其家属的合并症发生率明显高于一般人群。切除手术后较差的长期癫痫发作结果与患者的自闭症或认知障碍有关。总之，这些数据支持癫痫和中枢神经系统合并症之间的共同病理生理机制的证据。
Central nervous system (CNS) comorbidities have been identified in patients with epilepsy. Several of these comorbidities have been correlated with poor surgery outcomes in patient cohorts. The authors sought to determine if prevalence of comorbidities in pediatric epilepsy surgery patients and their families correlate with long-term seizure outcome in a cross-sectional analysis. Three-generation pedigrees were elicited to compare family history of epilepsy, ADHD, anxiety, autism, bipolar disorder, cognitive disability, depression, migraine, and motor disability to surgery outcomes in 52 patients. Proportions of affected patients and relatives were compared to general population comorbidity rates and the patients’ most recent seizure outcome classification. Patients and families had significantly higher rates of comorbidities than the general population. Poorer long-term seizure outcomes following resective surgery were associated with autism or cognitive disability in patients. Together these data support evidence for a common pathophysiological mechanism between epilepsy and CNS comorbidities.