Quality-of-life changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy
Quality-of-life changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy
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DOI：
10.1089/thy.1997.7.613
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发表时间：
1997-08-01
期刊：
影响因子：
6.6
通讯作者：
Anello, C
中科院分区：
文献类型：
--
作者：
Dow, KH;Ferrell, BR;Anello, C
生活质量（QOL）是一个重要的考虑因素，因为癌症患者存活时间更长，并且是甲状腺癌患者接受长期癌症监测的一个越来越感兴趣的领域。然而，很少有疾病特异性的生活质量工具可用于评估甲状腺癌患者的生活质量。这项纵向、重复测量研究的目的是：(1)在甲状腺激素停药期间测试一种新的工具——qol -甲状腺量表；(2)评估甲状腺激素停药对患者感知生活质量变化的影响。样本包括34名受试者（平均年龄40岁），他们正在接受甲状腺激素戒除，为扫描程序做准备。受试者在与扫描相关的四个特定时间点完成三种工具（人口统计数据工具，qol -甲状腺和FACT-G）。结果表明，QOL甲状腺工具是一种可靠、有效的QOL测量方法。QOL-Thyroid与FACT-G之间的Cronbach α系数r= 0.78，表明两者具有良好的并发效度。第二，甲状腺激素停药对生活质量的影响在四个测试点上表现出显著的生理、心理和社会幸福感变化。最大的变化发生在激素高峰停药和甲状腺素（T-4）治疗之间。虽然众所周知，患者会遭受与甲状腺激素戒断有关的麻烦的身体症状，但负面的心理，家庭和工作后遗症不太明显。总之，qol -甲状腺是一种可靠和有效的测量方法，用于评估接受扫描手术的患者，并可用于识别和针对患者生活中受激素戒断不良影响的高风险领域的教学和支持。
Quality of life (QOL) is an important consideration as patients survive longer with cancer and is an area of increasing interest in patients with thyroid cancer who undergo long-term cancer surveillance. However, there are few disease-specific QOL tools available to evaluate QOL in patients with thyroid cancer. The purposes of this longitudinal, repeated-measures study were to: (1) test a new instrument, the QOL-Thyroid Scale, during thyroid hormone withdrawal; and (2) to evaluate the impact of thyroid hormone withdrawal on patients' perceived changes in quality of life. The sample included 34 subjects (mean age 40 years) undergoing thyroid hormone withdrawal in preparation for scanning procedures. Subjects completed three instruments (demographic data tool, the QOL-Thyroid, and the FACT-G) at four specific time points in relationship to scanning. The results demonstrated that the QOL-Thyroid tool is a reliable and valid measure of QOL. Cronbach's alpha coefficient of r=.78 between QOL-Thyroid and FACT-G indicated good concurrent validity. Second, the impact of thyroid hormone withdrawal on QOL showed significant changes in physical, psychological, and social well-being across the four testing points. The greatest changes occurred between peak hormone withdrawal and thyroxine (T-4) therapy. While it is generally known that patients suffer troublesome physical symptoms relating to thyroid hormone withdrawal, the negative psychological, family, and work sequelae are less apparent. In conclusion, the QOL-Thyroid is a reliable and valid measure for use in evaluating patients undergoing scanning procedures and may be used to identify and target teaching and support for high-risk areas in patients lives that are negatively affected by hormone withdrawal.