Clinical significance of EphA2 expression in squamous-cell carcinoma of the head and neck
Clinical significance of EphA2 expression in squamous-cell carcinoma of the head and neck
复制标题
EphA2在头颈部鳞状细胞癌中表达的临床意义
DOI：
10.1007/s00432-010-0936-2
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发表时间：
2011-05-01
影响因子：
3.6
通讯作者：
Tian, Yongquan
中科院分区：
文献类型：
--
作者：
Liu, Yong;Zhang, Xin;Tian, Yongquan
目的：EphA2受体酪氨酸激酶在多种人类癌症中频繁过表达和功能改变。方法：采用免疫组织化学方法检测98例头颈部鳞状细胞癌（SCCHN）组织中EphA2的表达，并与临床病理参数进行相关性分析。结果：EphA2在SCCHN组织和SCCHN细胞系中均过表达。更重要的是，EphA2高表达分别与肿瘤部位、T分类、临床分期、复发和淋巴结转移显著相关。EphA2高表达患者的无病生存期和总生存期均低于EphA2低表达患者。多因素考克斯回归分析显示EphA2过表达是SCCHN患者的独立预后因素。结论：EphA2可能参与SCCHN的进展，是SCCHN患者的一个新的预后指标。
Purpose:EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in a variety of human cancers. The study aimed to assess EphA2 expression and to explore its roles in squamous-cell carcinoma of the head and neck (SCCHN).Methods:EphA2 expression in 98 primary SCCHN tissue specimens was analyzed by immunohistochemistry and correlated with clinicopathological parameters. Additionally, 13 paired SCCHN tissues and 6 SCCHN cell lines were evaluated for EphA2 expression by RT-PCR and immunoblotting.Results:EphA2 overexpressed in SCCHN tissues and SCCHN cell lines. More importantly, high EphA2 expression was significantly associated with tumor site, T classification, clinical stage, recurrence, and lymph node metastasis, respectively. Patients with high EphA2 expression had both poorer disease-free survival and overall survival than patients with low EphA2 expression. Multivariate Cox regression analysis revealed that EphA2 overexpression was an independent prognostic factor for patients with SCCHN.Conclusions:These findings suggested that EphA2 may contribute to SCCHN progression and represent a novel prognostic indicator for patients with SCCHN.