Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development
Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development
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DOI：
10.1016/j.celrep.2016.03.039
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发表时间：
2016-04-19
期刊：
影响因子：
8.8
通讯作者：
Takei, Fumio
中科院分区：
文献类型：
--
作者：
Ghaedi, Maryam;Steer, Catherine A.;Takei, Fumio
所有淋巴细胞都被认为是从共同的淋巴祖细胞（CLP）发育而来。然而，淋巴致敏的多能祖细胞（LMPP）在分化成T细胞和第2组先天淋巴样细胞（ILC 2）方面比CLP更有效。在此，我们将LMPP分为CD 127（-）（LMPP-s）和CD 127（+）（LMPP+s）亚群，并将其与Ly 6D（-）和Ly 6D（+）CLP进行比较。在移植试验中，成人LMPP+比其他祖细胞更快速有效地分化为T细胞和ILC。T细胞和ILC 2的发育在新生儿期高度活跃。新生儿CLP是罕见的，与突出的新生儿LMPP+不同，不能有效分化为T细胞和ILC 2。在新生儿期产生的ILC 2是长寿命的，并持续存在于成体组织中。这些结果表明，一些ILC和T细胞可能通过CLP非依赖性途径从LMPP+s发育而来。
All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we have divided LMPPs into CD127(-) (LMPP-s) and CD127(+) (LMPP+s) subsets and compared them with Ly6D(-) and Ly6D(+) CLPs. Adult LMPP+s differentiated into T cells and ILCs more rapidly and efficiently than other progenitors in transplantation assays. The development of T cells and ILC2s is highly active in the neonatal period. Neonatal CLPs are rare and, unlike prominent neonatal LMPP+s, do not efficiently differentiate into T cells and ILC2s. ILC2s generated in the neonatal period are long lived and persist in adult tissues. These results suggest that some ILCs and T cells may develop from LMPP+s via CLP-independent pathways.