Urdamycin L:: A novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717
Urdamycin L:: A novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717
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DOI：
10.1002/cbic.200390002
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发表时间：
2003-01-03
期刊：
影响因子：
3.2
通讯作者：
Rohr, J
中科院分区：
文献类型：
--
作者：
Rix, U;Remsing, LL;Rohr, J
由土壤细菌 Streptomyces fradiae T < 2717 产生的抗肿瘤抗生素乌达霉素 A（1；方案 1）是安古环素家族最重要的成员之一。在过去的几年中，在阐明这种聚酮化合物的生物合成途径方面已经取得了重大进展。[1±3]然而，
The antitumor antibiotic urdamycin A (1; Scheme 1) produced by the soil bacteria Streptomyces fradiae T‹ 2717 is one of the most prominent members of the angucycline family. Over the past few years, significant progress has been made in elucidation of the biosynthetic pathway of this polyketide compound.[1±3] However,