Noninvasive 24-h ambulatory blood pressure and cardiovascular disease: a systematic review and meta-analysis
Noninvasive 24-h ambulatory blood pressure and cardiovascular disease: a systematic review and meta-analysis
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DOI：
10.1097/hjh.0b013e3282f97854
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发表时间：
2008-07-01
影响因子：
4.9
通讯作者：
Bamberg, Fabian
中科院分区：
文献类型：
--
作者：
Conen, David;Bamberg, Fabian
目的系统评价无创24小时收缩压与心血管事件相关的证据。方法计算机检索PubMed、EMBASE和Cochrane图书馆至2007年4月。前瞻性跟踪至少100人至少1年，并报告至少一项感兴趣的效果评估的研究纳入其中。两名独立研究人员从研究设计、受试者特征、血压测量、结果评估、效果评估和潜在混杂因素调整等方面提取信息。结果我们根据15项独立队列研究确定了20篇符合条件的文章。在9项队列研究中评估了24小时收缩压和综合心血管终点之间的相关性，其中包括9299名参与者，他们被随访11.1年，发生了881起结果事件。24小时收缩压每升高10毫米汞的总危险比(95%可信区间)为1.27(1.18~1.38)(P
Objective We systematically assessed the evidence regarding the association between noninvasive 24-h systolic blood pressure and incident cardiovascular events.Methods We searched PubMed, EMBASE, and the Cochrane Library through April 2007. Studies that prospectively followed at least 100 individuals for at least 1 year, and that reported at least one effect estimate of interest were included. Two independent investigators abstracted information on study design, subject characteristics, blood pressure measurements, outcome assessment, effect estimates, and adjustment for potential confounders.Results We identified 20 eligible articles based on 15 independent cohort studies. The association between 24-h systolic blood pressure and a combined cardiovascular endpoint was assessed in nine cohort studies, including 9299 participants who were followed up to 11.1 years and had 881 outcome events. The summary hazard ratio (95% confidence interval) per 10-mmHg increase of 24-h systolic blood pressure was 1.27 (1.18-1.38) (P