RADIOBIOLOGICAL CONSIDERATIONS IN THE USE OF TOTAL-BODY IRRADIATION FOR BONE-MARROW TRANSPLANTATION
RADIOBIOLOGICAL CONSIDERATIONS IN THE USE OF TOTAL-BODY IRRADIATION FOR BONE-MARROW TRANSPLANTATION
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DOI：
10.1148/131.1.243
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发表时间：
1979-01-01
期刊：
影响因子：
19.7
通讯作者：
DICKE, KA
中科院分区：
文献类型：
--
作者：
PETERS, LJ;WITHERS, HR;DICKE, KA
根据放射生物学的理由，当为骨髓移植做准备的全身照射（TB1）作为分次疗程而不是以逻辑上合理的剂量率进行单次照射时，应该产生治疗[人类白血病]优势。这是因为与其他器官的细胞相比，造血来源的细胞一般显示出修复亚致死辐射损伤的能力较低。在分次TBl的情况下，剂量限制性肺耐受性估计为至少12Gy[格雷]（未经校正），无论剂量率如何，以2Gy的增量。描述了使用高能直线加速器输送TB1的实用方法。
On radiobiological grounds, a therapeutic [human leukemia] advantage should result when total body irradiation (TBl) in preparation for bone-marrow engraftment is given as a fractionated course rather than as a single exposure at logistically reasonable dose rates. This is because cells of hemopoietic origin in general show less capacity for repair of sublethal radiation injury than do cells of other organs Dose-limiting lung tolerance, in the context of fractionated TBl, is estimated to be at least 12 Gy [gray] (without correction) in increments of 2 Gy regardless of dose rate. A practical method for delivering TBl using a high energy linear accelerator is described.