Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: Five year follow-up of a prospective controlled study
Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: Five year follow-up of a prospective controlled study
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DOI：
10.1016/j.bone.2011.07.032
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发表时间：
2011-11-01
期刊：
影响因子：
4.1
通讯作者：
Hauzeur, Jean-Philippe
中科院分区：
文献类型：
--
作者：
Gangji, Valerie;De Maertelaer, Viviane;Hauzeur, Jean-Philippe
目的：探讨骨髓细胞植入术对股骨头坏死灶临床症状及股骨头坏死进展的影响，并与髓内减压术进行比较。方法：对19例24髋早期股骨头坏死患者进行研究。髋部被分配为只进行核心减压或核心减压并植入骨髓细胞。对于治疗组的分配，患者和评估者都是盲的。主要结局是临床症状和疾病进展。结果：骨髓移植能明显减轻疼痛和关节症状，降低骨折分期的发生率。在60个月时，对照组的11个髋关节中有8个恶化到骨折阶段，而骨髓移植组的13个髋关节中只有3个进展到骨折阶段。生存分析显示，两组在60个月时的失败时间有显著差异。患者在治疗后只有轻微的副作用。结论：本长期随访研究证实，自体骨髓细胞植入坏死病灶可能是早期股骨头坏死患者的有效治疗方法。(C) 2011爱思唯尔公司版权所有。
Objective: To determine the efficacy of bone marrow cell implantation into the necrotic lesion of the femoral head on clinical symptoms and the progression of osteonecrosis of the femoral head in comparison with core decompression.Methods: We studied nineteen patients and twenty four hips with early stage osteonecrosis of the femoral head. The hips were allocated to either core decompression only or core decompression and implantation of bone marrow cells. Both patients and assessors were blind with respect to treatment group assignment. The primary outcomes were clinical symptoms and disease progression.Results: Bone marrow implantation afforded a significant reduction in pain and in joint symptoms and reduced the incidence of fractural stages. At 60 months, eight of the eleven hips in the control group had deteriorated to the fractural stage whereas only three of the thirteen hips in the bone marrow graft group had progressed to that stage. Survival analysis showed a significant difference in the time to failure between the two groups at 60 months. Patients had only minor side-effects after the treatments.Conclusions: This long term follow-up study confirmed that implantation of autologous bone marrow cells in the necrotic lesion might be an effective treatment for patients with early stages of osteonecrosis of the femoral head. (C) 2011 Elsevier Inc. All rights reserved.