Clinical analyses of sighted patients with non-24-hour sleep-wake syndrome: A study of 57 consecutively diagnosed cases
Clinical analyses of sighted patients with non-24-hour sleep-wake syndrome: A study of 57 consecutively diagnosed cases
复制标题
DOI：
10.1093/sleep/28.8.945
复制
发表时间：
2005-08-01
期刊：
影响因子：
5.6
通讯作者：
Takahashi, K
中科院分区：
文献类型：
--
作者：
Hayakawa, T;Uchiyama, M;Takahashi, K
研究目的：本研究的目的是阐明患有非 24 小时睡眠觉醒综合征的视力正常患者的临床特征。设计：连续患有非 24 小时睡眠-觉醒综合征患者的临床分析。地点：日本国家神经病学和精神病学中心 Kohnodai 医院睡眠障碍诊所，患者：1991 年至 2001 年间连续诊断为非 24 小时睡眠-觉醒综合征的 57 名患者被纳入研究。测量和结果：分析患者的临床特征和睡眠特征。进行了半结构化精神病学访谈，其中包括《精神疾病诊断和统计手册》第三版修订版中轴 I 或 11 种疾病的标准，并分析了精神问题与非 24 小时睡眠觉醒综合征之间的关系。患者队列包括 41 名 (72%) 男性和 16 名 (28%) 女性。非 24 小时睡眠-觉醒综合征的发病发生在青少年时期，63% 的人群中，睡眠-觉醒周期的平均 (+/- SD) 周期为 24.9 +/- 0.4 小时（范围 24.4-26.5 小时）。患者的平均睡眠时间为 9.3 +/- 1.3 小时，其中 44% 的睡眠时间在 9 至 10 小时之间。 16 名患者（28%）在非 24 小时睡眠觉醒综合征发作之前曾患有精神疾病；其余 41 名患者中，有 14 名 (34%) 在非 24 小时睡眠觉醒综合征发作后出现重度抑郁症。结论：这些结果代表了对相对大量患有非 24 小时睡眠觉醒综合征的视力正常患者的首次详细临床审查。
Study Objectives: The objective of this study was to clarify the clinical features of sighted patients with non-24-hour sleep-wake syndrome. Design: Clinical analyses of consecutive patients suffering from non-24-hour sleep-wake syndrome.Setting: The sleep disorders clinic at Kohnodai Hospital, National Center of Neurology and Psychiatry, Japan,Patients: Fifty-seven patients who were diagnosed consecutively as having non-24-hour sleep-wake syndrome between 1991 and 2001 were included in the study.Measurements and Results: The clinical features and sleep characteristics of the patients were analyzed. A semistructured psychiatric interview that included the criteria for Axis I or 11 disorders of Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised was conducted, and relationships between psychiatric problems and non-24-hour sleep-wake syndrome were analyzed. The patient cohort included 41 (72%) men and 16 (28%) women. The onset of non-24-hour sleep-wake syndrome had occurred during the teenage years in 63% of the cohort, and the mean (+/- SD) period of the sleep-wake cycle was 24.9 +/- 0.4 hours (range 24.4-26.5 hours). The mean sleep length of the patients was 9.3 +/- 1.3 hours, and 44% of them had a sleep length of between 9 and 10 hours. Psychiatric disorders had preceded the onset of non-24-hour sleep-wake syndrome in 16 patients (28%); of the remaining 41 patients, 14 (34%) developed major depression after the onset of non-24-hour sleep-wake syndrome.Conclusions: These results represent the first detailed clinical review of a relatively large number of sighted patients with non-24-hour sleep-wake syndrome.