PARAMO: A Pipeline for Reconstructing Ancestral Anatomies Using Ontologies and Stochastic Mapping
PARAMO: A Pipeline for Reconstructing Ancestral Anatomies Using Ontologies and Stochastic Mapping
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PARAMO：使用本体和随机映射重建祖先解剖结构的管道
DOI：
10.1093/isd/ixz009
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发表时间：
2019
影响因子：
3.4
通讯作者：
Boudinot, Brendon
中科院分区：
文献类型：
--
作者：
Tarasov, Sergei;Mikó, István;Yoder, Matthew Jon;Uyeda, Josef C;Boudinot, Brendon
比较系统发育学在很大程度上缺乏一种方法来重建表型实体的进化，这些表型实体由多个离散特征的集合组成-整个生物体解剖或生物体区域。在这项研究中，我们提供了一种新的方法，通过映射本体)，适当地建模解剖依赖，并使用本体信息的随机映射图的融合来重建不同解剖层次上的表型进化，包括整个表型。这种方法为追踪表型辐射和生物解剖学的进化提供了新的机会。
Comparative phylogenetics has been largely lacking a method for reconstructing the evolution of phenotypic entities that consist of ensembles of multiple discrete traits—entire organismal anatomies or organismal body regions. In this study, we provide a new approach namedPARAMO(PhylogeneticAncestralReconstruction ofAnatomy byMappingOntologies) that appropriately models anatomical dependencies and uses ontology-informed amalgamation of stochastic maps to reconstruct phenotypic evolution at different levels of anatomical hierarchy including entire phenotypes. This approach provides new opportunities for tracking phenotypic radiations and evolution of organismal anatomies.