A PROSPECTIVE-STUDY OF FAMILY HISTORY AND THE RISK OF COLORECTAL-CANCER
A PROSPECTIVE-STUDY OF FAMILY HISTORY AND THE RISK OF COLORECTAL-CANCER
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DOI：
10.1056/nejm199412223312501
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发表时间：
1994-12-22
影响因子：
158.5
通讯作者：
WILLETT, WC
中科院分区：
文献类型：
--
作者：
FUCHS, CS;GIOVANNUCCI, EL;WILLETT, WC
背景。结直肠癌家族史被认为是该疾病的危险因素。然而，由于先前研究的回顾性设计，这种关联的强度是不确定的，特别是因为它受到高危人群和受影响家庭成员特征的影响。方法。我们对 32,085 名男性和 87,031 名女性进行了一项前瞻性研究，这些人之前未接受过结肠镜检查或乙状结肠镜检查，并提供了患有结直肠癌的一级亲属、饮食和其他疾病危险因素的数据。在随访期间，148 名男性和 315 名女性被诊断出结直肠癌。结果。与没有该疾病家族史的男性和女性相比，有一级亲属患病的男性和女性患结直肠癌的年龄调整相对风险为 1.72（95% 置信区间，1.34 至 2.19）。有两名或两名以上受影响的一级亲属的研究参与者的相对风险为 2.75（95% 置信区间，1.34 至 5.63）。对于 45 岁以下、有一名或多名一级亲属受影响的参与者，相对风险为 5.37（95% 置信区间，1.98 至 14.6），并且风险随着年龄的增加而降低（P 为趋势，
Background. A family history of colorectal cancer is recognized as a risk factor for the disease. However, as a result of the retrospective design of prior studies, the strength of this association is uncertain, particularly as it is influenced by characteristics of the person at risk and the affected family members.Methods. We conducted a prospective study of 32,085 men and 87,031 women who had not previously been examined by colonoscopy or sigmoidoscopy and who provided data on first-degree relatives with colorectal cancer, diet, and other risk factors for the disease. During the follow-up period, colorectal cancer was diagnosed in 148 men and 315 women.Results. The age-adjusted relative risk of colorectal cancer for men and women with affected first-degree relatives, as compared with those without a family history of the disease, was 1.72 (95 percent confidence interval, 1.34 to 2.19). The relative risk among study participants with two or more affected first-degree relatives was 2.75 (95 percent confidence interval, 1.34 to 5.63). For participants under the age of 45 years who had one or more affected first-degree relatives, the relative risk was 5.37 (95 percent confidence interval, 1.98 to 14.6), and the risk decreased with increasing age (P for trend,