Micro-RNA mediated regulation of proliferation, self-renewal and differentiation of mammalian stem cells
Micro-RNA mediated regulation of proliferation, self-renewal and differentiation of mammalian stem cells
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DOI：
10.4161/cam.3.4.9913
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发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Somers, W. Gregory
中科院分区：
文献类型：
--
作者：
Hime, Gary R.;Somers, W. Gregory
后生动物的生长和发育是由未分化的细胞群维持的，通常称为干细胞。干细胞具有几种特征性性质，包括通过自我更新分裂和产生分化为具有专门细胞命运的后代。已经鉴定了多种信号传导途径，其协调干细胞增殖与维持和分化。近年来，一些非蛋白质编码的小分子RNA（miRNAs）被发现在干细胞发育中起着重要的调节作用。单个miRNA能够指导许多mRNA靶标的翻译抑制，从而产生基因表达的广泛变化。此外，miRNA表达的功能障碍通常与癌症发展相关。癌症干细胞可能负责启动和维持肿瘤发生，与干细胞有许多相似之处，并且这两种细胞类型之间的一些miRNA功能机制可能是共同的。
Metazoan growth and development is maintained by populations of undifferentiated cells, commonly known as stem cells. Stem cells possess several characteristic properties, including dividing through self-renewing divisions and generating progeny that differentiate to have specialized cell fates. Multiple signaling pathways have been identified which coordinate stem cell proliferation with maintenance and differentiation. Relatively recently, the small, non-protein coding microRNAs (miRNAs) have been identified to function as important regulators in stem cell development. Individual miRNAs are capable of directing the translational repression of many mRNAs targets, generating widespread changes in gene expression. In addition, dysfunction of miRNA expression is commonly associated with cancer development. Cancer stem cells, which are likely responsible for initiating and maintaining tumorigenesis, share many similarities with stem cells and some mechanisms of miRNA function may be in common between these two cell types.