Expression profiles of osteosarcoma that can predict response to chemotherapy
Expression profiles of osteosarcoma that can predict response to chemotherapy
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DOI：
10.1158/0008-5472.can-05-0985
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发表时间：
2005-09-15
期刊：
影响因子：
11.2
通讯作者：
Lau, CC
中科院分区：
文献类型：
--
作者：
Man, TK;Chintagumpala, M;Lau, CC
骨肉瘤是儿童最常见的恶性骨肿瘤。在活检做出初步诊断后，治疗包括术前化疗，随后是最终手术和术后化疗。术前化疗对肿瘤坏死的反应程度是一个可靠的预后因素，可用于指导术后化疗的选择。肿瘤显示>= 90%坏死（反应良好）的患者预后比那些有
Osteosarcoma is the most common malignant bone tumor in children. After initial diagnosis is made with a biopsy, treatment consists of preoperative chemotherapy followed by definitive surgery and postoperative chemotherapy. The degree of tumor necrosis in response to preoperative chemotherapy is a reliable prognostic factor and is used to guide the choice of postoperative chemotherapy. Patients with tumors, which reveal >= 90% necrosis (good responders), have a much better prognosis than those with