TALEN‐mediated generation of Nkx3.1 knockout rat model
TALEN‐mediated generation of Nkx3.1 knockout rat model
复制标题
DOI：
10.1002/pros.24095
复制
发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Ji Min Lee;Ukjin Kim;Hyokyung Yang;Bokyeong Ryu;Jin Kim;Tetsushi Sakuma;Takashi Yamamoto;Jae‐Hak Park
中科院分区：
文献类型：
--
作者：
Ji Min Lee;Ukjin Kim;Hyokyung Yang;Bokyeong Ryu;Jin Kim;Tetsushi Sakuma;Takashi Yamamoto;Jae‐Hak Park
利用转录激活物样效应核酸酶(TALEN)进行基因编辑的最新进展，极大地帮助了基因工程动物模型的产生。NK3 Homeobox 1(NKX3.1)蛋白在前列腺发育和蛋白质合成中发挥重要作用，并发挥肿瘤抑制作用。最近，NKX3.1被证明与人类乳腺癌有关。
Recent developments in gene editing, using transcriptional activator‐like effector nucleases (TALENs), have greatly helped the generation of genetically engineered animal models. The NK3 homeobox 1 (NKX3.1) protein plays important roles in prostate development and protein production, and functions as a tumor suppressor. Recently, NKX3.1 was shown to be associated with breast cancer in humans.