Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
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中国东部女性驱动蛋白样因子 1 B 基因多态性与上皮性卵巢癌风险。
DOI：
10.1007/s13277-015-3394-2
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Wei Qingyi
中科院分区：
文献类型：
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作者：
Shi Ting-Yan;Jiang Zhi;Jiang Rong;Yin Sheng;Wang Meng-Yun;Yu Ke-Da;Shao Zhi-Ming;Sun Meng-Hong;Zang Rongyu;Wei Qingyi
驱动蛋白样因子1 B（KIF 1 B）基因在细胞凋亡和恶性肿瘤的发生、发展过程中起重要作用。KIF 1B的遗传变异可能导致上皮性卵巢癌（EOC）的风险。在这项研究中，1,324例EOC患者和1,386例无癌女性对照，我们通过条件Logistic回归分析研究了KIF 1和EOC风险中两个潜在功能性单核苷酸多态性之间的关系。采用一般线性回归模型分析突变等位基因数与KIF 1BmRNA表达水平的相关性。我们发现，与AA基因型相比，rs 17401966变异体AG/GG基因型与EOC风险降低显著相关（校正比值比（OR）= 0.81，95%置信区间（CI）= 0.68-0.97），但未观察到rs 1002076相关性。携带KIF 1B基因rs 17401966 AG/GG和rs 1002076 AG/AA两种基因型的妇女与其他人相比，其风险降低0.82倍（调整后的95%CI = 0.69-0.97）。此外，没有证据表明上述共变体之间可能存在相互作用。进一步的基因型-表型相关分析表明，rs 17401966变异G等位基因的数目与KIF 1BmRNA表达水平显著相关（P在所有受试者和中国受试者中GLM分别为0.003和0.001），GG携带者KIF 1BmRNA表达水平最低。综上所述，rs 17401966多态性可能调节KIF 1BmRNA的表达，因此可能与中国东部妇女EOC的风险有关。更大规模的独立研究是必要的，以验证我们的发现。
Thekinesin-like factor 1 B(KIF1B) gene plays an important role in the process of apoptosis and the transformation and progression of malignant cells. Genetic variations inKIF1Bmay contribute to risk of epithelial ovarian cancer (EOC). In this study of 1,324 EOC patients and 1,386 cancer-free female controls, we investigated associations between two potentially functional single nucleotide polymorphisms inKIF1Band EOC risk by the conditional logistic regression analysis. General linear regression model was used to evaluate the correlation between the number of variant alleles andKIF1BmRNA expression levels. We found that the rs17401966 variant AG/GG genotypes were significantly associated with a decreased risk of EOC (adjusted odds ratio (OR) = 0.81, 95 % confidence interval (CI) = 0.68–0.97), compared with the AA genotype, but no associations were observed for rs1002076. Women who carried both rs17401966 AG/GG and rs1002076 AG/AA genotypes ofKIF1Bhad a 0.82-fold decreased risk (adjusted 95 % CI = 0.69–0.97), compared with others. Additionally, there was no evidence of possible interactions between about-mentioned co-variants. Further genotype-phenotype correlation analysis indicated that the number of rs17401966 variant G allele was significantly associated withKIF1BmRNA expression levels (Pfor GLM = 0.003 and 0.001 in all and Chinese subjects, respectively), with GG carriers having the lowest level ofKIF1BmRNA expression. Taken together, the rs17401966 polymorphism likely regulatesKIF1BmRNA expression and thus may be associated with EOC risk in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.