In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY)
In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY)
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DOI：
10.1016/j.vaccine.2008.02.046
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发表时间：
2008-04-16
期刊：
影响因子：
5.5
通讯作者：
Kodama, Yoshikatsu
中科院分区：
文献类型：
--
作者：
Ibrahim, El-Sayed Moustafa;Rahman, A. K. M. Shofiqur;Kodama, Yoshikatsu
We prepared anti-Candida albicans antibody in chicken egg yolk (anti-CA IgY) and investigated its in vitro and in vivo effectiveness. Anti-CA IgY significantly reduced the adherence capacity of C. albicans to FaDu cells (human pharynx carcinoma cells) in a dose-dependent manner. The protective efficacy of anti-CA IgY was investigated in experimentally induced oral. candidiasis in immunosuppressed mice. Oral administration of anti-CA IgY significantly reduced the number of C. albicans and the scores of the tongue lesions. Moreover, anti-CA IgY reduced the colonization of C. albicans in mice organs. These results indicate that anti-CA IgY has a protective effect against the oral candidiasis of experimentally infected mice and reduces the dissemination of C. albicans. Putting together, these results indicate that anti-CA IgY is effective against C. albicans. This effect might be due to the blocking of the binding of C. albicans to the host cells. Therefore, anti-CA IgY might be considered as a prophylactic immunotherapy or possibly an adjunctive antifungal. therapy. (C) 2008 Elsevier Ltd. All rights reserved.
