Mechanisms of action of the implantable gastric stimulator for obesity
Mechanisms of action of the implantable gastric stimulator for obesity
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DOI：
10.1007/bf03342135
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发表时间：
2004-09-01
期刊：
影响因子：
2.9
通讯作者：
Chen, JD
中科院分区：
文献类型：
--
作者：
Chen, JD
植入式胃刺激器（IGSO）已被用于治疗肥胖症，具有良好的效果。然而，与使用IGS治疗肥胖相关的可能机制尚未得到很好的理解。根据最近的临床和基础研究，似乎IGS降低食欲并增加饱腹感，这归因于其对胃运动的抑制作用及其对中枢神经系统和与饱腹感和/或食欲相关的激素的直接影响。已经表明，慢性胃刺激在进食状态下损害固有胃肌电活动，在禁食状态下诱导胃扩张并抑制餐后胃窦收缩。胃肌电活动和收缩的受损与胃的消化和排空受损相关，这可能导致早饱和食物摄入减少。在禁食状态下胃扩张的诱导导致牵张感受器的激活，引起饱腹感。还显示IGS可对中枢神经系统和某些激素具有直接调节作用。IGS对神经元活动的调节和某些激素的释放也可以解释食欲下降和饱腹感增加的原因。
An implantable gastric stimulator (IGSO) has been used for the treatment of obesity with promising results. However, possible mechanisms involved with the treatment of obesity using an IGS are not well understood. According to recent clinical and basic studies, it seems that an IGS reduces appetite and increases satiety, attributed to its inhibitory effects on gastric motility and its direct effects on the central nervous system and hormones related to satiety and/or appetite. It has been indicated that chronic gastric stimulation impairs intrinsic gastric myoelectrical activity in the fed state, induces gastric distention in the fasting state and inhibits postprandial antral contractions. The impairment of gastric myoelectrical activity and contractions is associated with impaired digestion and emptying of the stomach, which may lead to early satiety and reduced food intake. The induction of gastric distention in the fasting state results in activation of stretch receptors, causing satiety. It has also been shown that an IGS may have direct regulatory effects on the central nervous system and certain hormones. Modulation of neuronal activities and release of certain hormones with an IGS may also explain the reduction of appetite and the increase of satiety.