Perinatal Iron Deficiency Combined with a High-Fat Diet Causes Obesity and Cardiovascular Dysregulation
Perinatal Iron Deficiency Combined with a High-Fat Diet Causes Obesity and Cardiovascular Dysregulation
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DOI：
10.1210/en.2011-1700
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发表时间：
2012-03-01
期刊：
影响因子：
4.8
通讯作者：
Nakatsu, Kanji
中科院分区：
文献类型：
--
作者：
Bourque, Stephane L.;Komolova, Marina;Nakatsu, Kanji
食用高脂肪西方饮食（WD）以及由此导致的肥胖与许多慢性疾病有关，包括心血管失调。本研究的目的是确定围产期缺铁 (PID) 加上 WD 的摄入是否会导致成年后代出现肥胖表型，从而加剧代谢和心血管结局。雌性 Sprague Dawley 大鼠在妊娠前和整个妊娠期间喂食对照（225 mg/kg Fe）或铁限制饮食（3-10 mg/kg Fe）。出生时，所有母鼠都喂食富含铁的饮食。断奶时，子代接受正常饮食或 WD 喂养长达 21 周。从 15 周龄开始，通过无线电遥测评估血流动力学和运动活动。怀孕期间限制铁的摄入会导致母鼠和后代严重贫血，导致后代出生体重降低 15%。与正常饮食喂养的同窝仔鼠相比，喂食 WD 的 PID 后代的热量摄入量更高，并且表现出运动活性降低；在正常铁控制后代中没有观察到这种效应。尽管对血清脂质谱有类似的影响，但 WD 的摄入对 PID 组的体重影响更大，而这种体重增加主要是由于内脏脂肪组织的积累。在 PID 后代中观察到内脏脂肪组织重量与平均动脉压之间存在显着相关性，但在对照组中则不然。这些观察结果表明，PID 使后代对 WD 的反应增强，其特征是脂肪积累增加和心血管失调。 （内分泌学153：1174-1182，2012）
Consumption of a high-fat Western diet (WD) and the resultant obesity is linked to a number of chronic pathologies, including cardiovascular dysregulation. The purpose of the present study was to determine whether perinatal iron deficiency (PID) added to the consumption of a WD would precipitate an obese phenotype with exacerbated metabolic and cardiovascular outcomes in adult offspring. Female Sprague Dawley rats were fed either a control (225 mg/kg Fe) or an iron-restricted diet (3-10 mg/kg Fe) prior to and throughout gestation. At birth, all dams were fed an iron-replete diet. At weaning, offspring were fed a normal diet or WD for up to 21 wk. Hemodynamics and locomotor activity were assessed by radiotelemetry starting at 15 wk of age. Iron restriction during pregnancy caused severe anemia in dams and offspring, resulting in 15% lower birth weights in the offspring. PID offspring fed the WD had greater caloric intake and exhibited reduced locomotor activity compared with their normal diet-fed littermates; no such effects were observed in normal iron control offspring. Despite having a similar effect on serum lipid profiles, consumption of the WD had a greater impact on body weight in the PID group, and this weight gain was due largely to visceral adipose tissue accumulation. A significant correlation between visceral adipose tissue weight and mean arterial pressure was observed in the PID offspring but not in controls. These observations demonstrate that PID predisposes offspring to an enhanced response to WD characterized by increased fat accumulation and cardiovascular dysregulation. (Endocrinology 153: 1174-1182, 2012)