Geographic dynamics of viral encephalitis in Thailand
Geographic dynamics of viral encephalitis in Thailand
复制标题
DOI：
10.1016/s1286-4579(03)00100-x
复制
发表时间：
2003-06-01
影响因子：
5.8
通讯作者：
Gonzalez, JP
中科院分区：
文献类型：
--
作者：
Henrich, TJ;Hutchaleelaha, S;Gonzalez, JP
病毒性脑炎（VE）仍然是亚洲的一种主要疾病，引起的严重疾病可能导致死亡或神经系统后遗症。本研究涉及的气候，地理和季节性模式的临床报告VE在泰国1993年至1998年的生态分析，调查疾病发病率的区域和季节性差异。研究期间，泰国公共卫生部在全国范围内临床诊断出3829例VE病例。进行了时间、空间和地理变量与疾病发病率的斯皮尔曼等级相关分析。在泰国东北部地区，VE的月发病率与温度、相对湿度和降雨量的季节变化显著相关（P < 0.001），而中南部地区的发病率仅与相对湿度相关（P = 0.003）。空间分析显示，东北部地区病害与海拔高度正相关（P < 0.001），与稻田覆盖（P < 0.001）、农业土地利用（P < 0.001）和温度（P = 0.004）呈负相关。在中南部地区没有发现明显的空间相关性。VE的空间分布表明，病因的变化可能是负责的，在一定程度上，疾病的地理模式。为了给医生提供疾病预防和临床管理所需的信息，在不同的地理环境中进行积极的病原学监测是必要的。(C)2003年，Elsevier SAS科学与医学版。All rights reserved.
Viral encephalitis (VE) continues to be a major disease in Asia, causing serious illness which may result in death or have neurological sequelae. This study involves an ecological analysis of the climatic, geographic and seasonal patterns of clinically reported VE in Thailand from 1993 to 1998 to investigate regional and seasonal differences in disease incidence. Three thousand eight hundred and twenty nine cases of VE were clinically diagnosed nationwide during the study period by the Thai Ministry of Public Health. Spearman rank correlations of temporal, spatial and geographic variables with disease incidence were performed. The monthly incidence of VE correlated significantly with seasonal changes in temperature, relative humidity and rainfall in the north-northeast region of Thailand (P < 0.001), whereas incidence in the south-central region correlated only with relative humidity (P = 0.003). Spatial analysis revealed a positive correlation of disease with elevation (P < 0.001), and negative correlations with rice-field cover (P < 0.001), agricultural land-use (P < 0.001) and temperature (P = 0.004) in the north-northeast region. No significant spatial correlation was identified in the south-central region. The spatial distribution of VE suggests that etiologic variations may be responsible, in part, for the geographic patterns of disease. Active etiologic surveillance is necessary in a variety of geographic settings in order to provide physicians with information necessary for disease prevention and clinical management. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.