Changing paradigms in dermatology:: Confocal microscopy in clinical and surgical dermatology
Changing paradigms in dermatology:: Confocal microscopy in clinical and surgical dermatology
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DOI：
10.1016/j.clindermatol.2003.08.007
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发表时间：
2003-09-01
影响因子：
2.7
通讯作者：
Torres, A
中科院分区：
文献类型：
--
作者：
González, S;Swindells, K;Torres, A
目前病理学和皮肤病理学的实践依赖于以某种方式对从患者身上取出的组织进行评估，然后进行处理和染色。虽然这种方法可以实现高分辨率的细节，但也有一定的风险和缺点。最新的成像技术现在有可能实现对患者原位病变的无创高分辨率分析。其中，反射模式共聚焦显微镜提供了可与常规组织学相媲美的最高分辨率成像。由于是完全非侵入性的，皮肤可以在其自然的、动态的状态下被观察到。本章将回顾体内共聚焦成像的基本原理及其在普通和外科皮肤科的临床应用。
The current practice of pathology and dermatopathology depends upon the evaluation of tissue in some manner extirpated from the patient and then processed and stained. While high resolution of detail can be accomplished by this method, there are certain risks and disadvantages. Recent imaging techniques now allow for a potential of achieving noninvasive high-resolution analysis of lesions in situ in the patient. Of these, Reflectance mode confocal microscopy offers the highest resolution imaging comparable to routine histology. Being entirely non invasive, skin can be observed in its native, dynamic state. This chapter will review the fundamentals of in vivo confocal imaging and the clinical applications in general and surgical dermatology.