Stressful life events and risk of breast cancer in 10,808 women: A cohort study
Stressful life events and risk of breast cancer in 10,808 women: A cohort study
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DOI：
10.1093/aje/kwg002
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发表时间：
2003-03-01
影响因子：
5
通讯作者：
Koskenvuo, M
中科院分区：
文献类型：
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作者：
Lillberg, K;Verkasalo, PK;Koskenvuo, M
作者前瞻性地调查了来自芬兰双胞胎队列的10808名妇女的压力生活事件与乳腺癌风险之间的关系。1981年通过自填问卷对生活事件和乳腺癌风险因素进行了评估。使用了标准化生活事件清单的国家修订，检查生活事件的积累和个人生活事件，并将重点放在完成问卷前的5年。通过与芬兰癌症登记处的记录联系，在1982年至1996年期间确定了180例乳腺癌事件。生活事件总数每增加一个事件，乳腺癌的多变量调整风险比为1.07（95%可信区间（CI）： 1.00, 1.15）。当只考虑生活中的重大事件时，该风险估计上升到1.35 （95% CI: 1.09, 1.67）。与生活事件无关，离婚/分居（风险比(HR)=2.26, 95% CI: 1.25, 4.07）、丈夫死亡（HR=2.00, 95% CI: 1.03, 3.88）、近亲或朋友死亡（HR=1.36, 95% CI: 1.00, 1.86）都与乳腺癌风险增加有关。研究结果表明，生活事件通过激素或其他机制在乳腺癌病因学中发挥作用。
The authors prospectively investigated the relation between stressful life events and risk of breast cancer among 10,808 women from the Finnish Twin Cohort. Life events and breast cancer risk factors were assessed by self-administered questionnaire in 1981. A national modification of a standardized life event inventory was used, examining accumulation of life events and individual life events and placing emphasis on the 5 years preceding completion of the questionnaire. Through record linkage with the Finnish Cancer Registry, 180 incident cases of breast cancer were identified in the cohort between 1982 and 1996. The multivariable adjusted hazard ratio for breast cancer per one-event increase in the total number of life events was 1.07 (95% confidence interval (CI): 1.00, 1.15). This risk estimate rose to 1.35 (95% CI: 1.09, 1.67) when only major life events were taken into account. Independently of total life events, divorce/separation (hazard ratio (HR)=2.26, 95% CI: 1.25, 4.07), death of a husband (HR=2.00, 95% CI: 1.03, 3.88), and death of a close relative or friend (HR=1.36, 95% CI: 1.00, 1.86) were all associated with increased risk of breast cancer. The findings suggest a role for life events in breast cancer etiology through hormonal or other mechanisms.